Skiles GL - Search Results

1

Metabolite generation via microbial biotransformations with Actinomycetes: rapid screening for active strains and biosynthesis of important human metabolites of two development-stage compounds, 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101) and dasatinib.

Li W, Josephs JL, Skiles GL, Humphreys WG. Li W, et al. Among authors: skiles gl. Drug Metab Dispos. 2008 Apr;36(4):721-30. doi: 10.1124/dmd.107.019570. Epub 2008 Jan 28. Drug Metab Dispos. 2008. PMID: 18227141

2

Detection and characterization of metabolites in biological matrices using mass defect filtering of liquid chromatography/high resolution mass spectrometry data.

Zhu M, Ma L, Zhang D, Ray K, Zhao W, Humphreys WG, Skiles G, Sanders M, Zhang H. Zhu M, et al. Drug Metab Dispos. 2006 Oct;34(10):1722-33. doi: 10.1124/dmd.106.009241. Epub 2006 Jun 30. Drug Metab Dispos. 2006. PMID: 16815965

3

Reductive isoxazole ring opening of the anticoagulant razaxaban is the major metabolic clearance pathway in rats and dogs.

Zhang D, Raghavan N, Chen SY, Zhang H, Quan M, Lecureux L, Patrone LM, Lam PY, Bonacorsi SJ, Knabb RM, Skiles GL, He K. Zhang D, et al. Among authors: skiles gl. Drug Metab Dispos. 2008 Feb;36(2):303-15. doi: 10.1124/dmd.107.018416. Epub 2007 Nov 5. Drug Metab Dispos. 2008. PMID: 17984286

4

Biosynthesis of drug metabolites using microbes in hollow fiber cartridge reactors: case study of diclofenac metabolism by Actinoplanes species.

Osorio-Lozada A, Surapaneni S, Skiles GL, Subramanian R. Osorio-Lozada A, et al. Among authors: skiles gl. Drug Metab Dispos. 2008 Feb;36(2):234-40. doi: 10.1124/dmd.107.019323. Epub 2007 Nov 15. Drug Metab Dispos. 2008. PMID: 18006646

5

Nonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide).

Subramanian R, Zhu X, Kerr SJ, Esmay JD, Louie SW, Edson KZ, Walter S, Fitzsimmons M, Wagner M, Soto M, Pham R, Wilson SF, Skiles GL. Subramanian R, et al. Among authors: skiles gl. Drug Metab Dispos. 2016 Aug;44(8):1319-31. doi: 10.1124/dmd.115.068007. Epub 2016 Feb 19. Drug Metab Dispos. 2016. PMID: 26895981

6

A novel biotransformation of alkyl aminopyrrolidine to aminopiperidine ring by human CYP3A.

Chen Y, Skiles GL, Shou M, Hickman D, Hsieh F. Chen Y, et al. Among authors: skiles gl. Drug Metab Dispos. 2011 Sep;39(9):1668-73. doi: 10.1124/dmd.111.039750. Epub 2011 Jun 14. Drug Metab Dispos. 2011. PMID: 21673127

7

Modeling, prediction, and in vitro in vivo correlation of CYP3A4 induction.

Shou M, Hayashi M, Pan Y, Xu Y, Morrissey K, Xu L, Skiles GL. Shou M, et al. Among authors: skiles gl. Drug Metab Dispos. 2008 Nov;36(11):2355-70. doi: 10.1124/dmd.108.020602. Epub 2008 Jul 31. Drug Metab Dispos. 2008. PMID: 18669588

8

Prediction of human drug-drug interactions from time-dependent inactivation of CYP3A4 in primary hepatocytes using a population-based simulator.

Xu L, Chen Y, Pan Y, Skiles GL, Shou M. Xu L, et al. Among authors: skiles gl. Drug Metab Dispos. 2009 Dec;37(12):2330-9. doi: 10.1124/dmd.108.025494. Epub 2009 Sep 22. Drug Metab Dispos. 2009. PMID: 19773538

9

Simulation of clinical drug-drug interactions from hepatocyte CYP3A4 induction data and its potential utility in trial designs.

Xu Y, Zhou Y, Hayashi M, Shou M, Skiles GL. Xu Y, et al. Among authors: skiles gl. Drug Metab Dispos. 2011 Jul;39(7):1139-48. doi: 10.1124/dmd.111.038067. Epub 2011 Mar 25. Drug Metab Dispos. 2011. PMID: 21441468

10

Cytochrome P450-mediated epoxidation of 2-aminothiazole-based AKT inhibitors: identification of novel GSH adducts and reduction of metabolic activation through structural changes guided by in silico and in vitro screening.

Subramanian R, Lee MR, Allen JG, Bourbeau MP, Fotsch C, Hong FT, Tadesse S, Yao G, Yuan CC, Surapaneni S, Skiles GL, Wang X, Wohlhieter GE, Zeng Q, Zhou Y, Zhu X, Li C. Subramanian R, et al. Among authors: skiles gl. Chem Res Toxicol. 2010 Mar 15;23(3):653-63. doi: 10.1021/tx900414g. Chem Res Toxicol. 2010. PMID: 20095585

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