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A Randomized, Double-Blind, Placebo-Controlled, First-Time-in-Human Study to Assess the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of GSK3389404 in Healthy Subjects.
Han K, Cremer J, Elston R, Oliver S, Baptiste-Brown S, Chen S, Gardiner D, Davies M, Saunders J, Hamatake R, Losos J, Leivers M, Hood S, van der Berg F, Paff M, Ritter JM, Theodore D. Han K, et al. Among authors: theodore d. Clin Pharmacol Drug Dev. 2019 Aug;8(6):790-801. doi: 10.1002/cpdd.670. Epub 2019 Mar 12. Clin Pharmacol Drug Dev. 2019. PMID: 30861337 Free PMC article. Clinical Trial.
Lack of clinically significant pharmacokinetic interaction between the thrombopoietin receptor agonist eltrombopag and hepatitis C virus protease inhibitors boceprevir and telaprevir.
Wire MB, Fang L, Hussaini A, Kleha JF, Theodore D. Wire MB, et al. Among authors: theodore d. Antimicrob Agents Chemother. 2014 Nov;58(11):6704-9. doi: 10.1128/AAC.03091-14. Epub 2014 Aug 25. Antimicrob Agents Chemother. 2014. PMID: 25155600 Free PMC article. Clinical Trial.
Erratum for Wire et al., Lack of clinically significant pharmacokinetic interaction between the thrombopoietin receptor agonist eltrombopag and hepatitis C virus protease inhibitors boceprevir and telaprevir.
Wire MB, Fang L, Hussaini A, Kleha JF, Theodore D. Wire MB, et al. Among authors: theodore d. Antimicrob Agents Chemother. 2015 May;59(5):2969. doi: 10.1128/AAC.00567-15. Antimicrob Agents Chemother. 2015. PMID: 25862822 Free PMC article. No abstract available.
Eltrombopag for children with chronic immune thrombocytopenia (PETIT2): a randomised, multicentre, placebo-controlled trial.
Grainger JD, Locatelli F, Chotsampancharoen T, Donyush E, Pongtanakul B, Komvilaisak P, Sosothikul D, Drelichman G, Sirachainan N, Holzhauer S, Lebedev V, Lemons R, Pospisilova D, Ramenghi U, Bussel JB, Bakshi KK, Iyengar M, Chan GW, Chagin KD, Theodore D, Marcello LM, Bailey CK. Grainger JD, et al. Among authors: theodore d. Lancet. 2015 Oct 24;386(10004):1649-58. doi: 10.1016/S0140-6736(15)61107-2. Epub 2015 Jul 28. Lancet. 2015. PMID: 26231455 Clinical Trial.
Social stigmatization and hepatitis C virus infection.
Zacks S, Beavers K, Theodore D, Dougherty K, Batey B, Shumaker J, Galanko J, Shrestha R, Fried MW. Zacks S, et al. Among authors: theodore d. J Clin Gastroenterol. 2006 Mar;40(3):220-4. doi: 10.1097/00004836-200603000-00009. J Clin Gastroenterol. 2006. PMID: 16633123
Eltrombopag increases platelet numbers in thrombocytopenic patients with HCV infection and cirrhosis, allowing for effective antiviral therapy.
Afdhal NH, Dusheiko GM, Giannini EG, Chen PJ, Han KH, Mohsin A, Rodriguez-Torres M, Rugina S, Bakulin I, Lawitz E, Shiffman ML, Tayyab GU, Poordad F, Kamel YM, Brainsky A, Geib J, Vasey SY, Patwardhan R, Campbell FM, Theodore D. Afdhal NH, et al. Among authors: theodore d. Gastroenterology. 2014 Feb;146(2):442-52.e1. doi: 10.1053/j.gastro.2013.10.012. Epub 2013 Oct 12. Gastroenterology. 2014. PMID: 24126097 Clinical Trial.
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