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Page 1
Large-scale purification of human BACE expressed in mammalian cells and removal of the prosegment with HIV-1 protease to improve crystal diffraction.
Emmons TL, Shuck ME, Babcock MS, Holloway JS, Leone JW, Durbin JD, Paddock DJ, Prince DB, Heinrikson RL, Fischer HD, Bienkowski MJ, Benson TE, Tomasselli AG. Emmons TL, et al. Among authors: bienkowski mj. Protein Pept Lett. 2008;15(2):119-30. doi: 10.2174/092986608783489599. Protein Pept Lett. 2008. PMID: 18289104
Design of potent inhibitors of human beta-secretase. Part 1.
Freskos JN, Fobian YM, Benson TE, Bienkowski MJ, Brown DL, Emmons TL, Heintz R, Laborde A, McDonald JJ, Mischke BV, Molyneaux JM, Moon JB, Mullins PB, Bryan Prince D, Paddock DJ, Tomasselli AG, Winterrowd G. Freskos JN, et al. Among authors: bienkowski mj. Bioorg Med Chem Lett. 2007 Jan 1;17(1):73-7. doi: 10.1016/j.bmcl.2006.09.092. Epub 2006 Oct 4. Bioorg Med Chem Lett. 2007. PMID: 17046251
Design of potent inhibitors of human beta-secretase. Part 2.
Freskos JN, Fobian YM, Benson TE, Moon JB, Bienkowski MJ, Brown DL, Emmons TL, Heintz R, Laborde A, McDonald JJ, Mischke BV, Molyneaux JM, Mullins PB, Bryan Prince D, Paddock DJ, Tomasselli AG, Winterrowd G. Freskos JN, et al. Among authors: bienkowski mj. Bioorg Med Chem Lett. 2007 Jan 1;17(1):78-81. doi: 10.1016/j.bmcl.2006.09.091. Epub 2006 Oct 4. Bioorg Med Chem Lett. 2007. PMID: 17049233
Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1.
Kortum SW, Benson TE, Bienkowski MJ, Emmons TL, Prince DB, Paddock DJ, Tomasselli AG, Moon JB, LaBorde A, TenBrink RE. Kortum SW, et al. Among authors: bienkowski mj. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3378-83. doi: 10.1016/j.bmcl.2007.03.096. Epub 2007 Apr 3. Bioorg Med Chem Lett. 2007. PMID: 17434734
The titerless infected-cells preservation and scale-up (TIPS) method for large-scale production of NO-sensitive human soluble guanylate cyclase (sGC) from insect cells infected with recombinant baculovirus.
Wasilko DJ, Lee SE, Stutzman-Engwall KJ, Reitz BA, Emmons TL, Mathis KJ, Bienkowski MJ, Tomasselli AG, Fischer HD. Wasilko DJ, et al. Among authors: bienkowski mj. Protein Expr Purif. 2009 Jun;65(2):122-32. doi: 10.1016/j.pep.2009.01.002. Epub 2009 Jan 11. Protein Expr Purif. 2009. PMID: 19174191
Employing a superior BACE1 cleavage sequence to probe cellular APP processing.
Tomasselli AG, Qahwash I, Emmons TL, Lu Y, Leone JW, Lull JM, Fok KF, Bannow CA, Smith CW, Bienkowski MJ, Heinrikson RL, Yan R. Tomasselli AG, et al. Among authors: bienkowski mj. J Neurochem. 2003 Mar;84(5):1006-17. doi: 10.1046/j.1471-4159.2003.01597.x. J Neurochem. 2003. PMID: 12603825 Free article.
Human beta-secretase (BACE) and BACE inhibitors.
John V, Beck JP, Bienkowski MJ, Sinha S, Heinrikson RL. John V, et al. Among authors: bienkowski mj. J Med Chem. 2003 Oct 23;46(22):4625-30. doi: 10.1021/jm030247h. J Med Chem. 2003. PMID: 14561080 Review. No abstract available.
49 results