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Clinical emergence of entecavir-resistant hepatitis B virus requires additional substitutions in virus already resistant to Lamivudine.
Tenney DJ, Levine SM, Rose RE, Walsh AW, Weinheimer SP, Discotto L, Plym M, Pokornowski K, Yu CF, Angus P, Ayres A, Bartholomeusz A, Sievert W, Thompson G, Warner N, Locarnini S, Colonno RJ. Tenney DJ, et al. Antimicrob Agents Chemother. 2004 Sep;48(9):3498-507. doi: 10.1128/AAC.48.9.3498-3507.2004. Antimicrob Agents Chemother. 2004. PMID: 15328117 Free PMC article.
Entecavir resistance is rare in nucleoside naïve patients with hepatitis B.
Colonno RJ, Rose R, Baldick CJ, Levine S, Pokornowski K, Yu CF, Walsh A, Fang J, Hsu M, Mazzucco C, Eggers B, Zhang S, Plym M, Klesczewski K, Tenney DJ. Colonno RJ, et al. Hepatology. 2006 Dec;44(6):1656-65. doi: 10.1002/hep.21422. Hepatology. 2006. PMID: 17133475 Clinical Trial.
Two-year assessment of entecavir resistance in Lamivudine-refractory hepatitis B virus patients reveals different clinical outcomes depending on the resistance substitutions present.
Tenney DJ, Rose RE, Baldick CJ, Levine SM, Pokornowski KA, Walsh AW, Fang J, Yu CF, Zhang S, Mazzucco CE, Eggers B, Hsu M, Plym MJ, Poundstone P, Yang J, Colonno RJ. Tenney DJ, et al. Antimicrob Agents Chemother. 2007 Mar;51(3):902-11. doi: 10.1128/AAC.00833-06. Epub 2006 Dec 18. Antimicrob Agents Chemother. 2007. PMID: 17178796 Free PMC article. Clinical Trial.
Inhibition of hepatitis B virus polymerase by entecavir.
Langley DR, Walsh AW, Baldick CJ, Eggers BJ, Rose RE, Levine SM, Kapur AJ, Colonno RJ, Tenney DJ. Langley DR, et al. J Virol. 2007 Apr;81(8):3992-4001. doi: 10.1128/JVI.02395-06. Epub 2007 Jan 31. J Virol. 2007. PMID: 17267485 Free PMC article.
96 results