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The thiazolobenzimidazole TBZE-029 inhibits enterovirus replication by targeting a short region immediately downstream from motif C in the nonstructural protein 2C.
De Palma AM, Heggermont W, Lanke K, Coutard B, Bergmann M, Monforte AM, Canard B, De Clercq E, Chimirri A, Pürstinger G, Rohayem J, van Kuppeveld F, Neyts J. De Palma AM, et al. Among authors: canard b. J Virol. 2008 May;82(10):4720-30. doi: 10.1128/JVI.01338-07. Epub 2008 Mar 12. J Virol. 2008. PMID: 18337578 Free PMC article.
A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase.
Paeshuyse J, Leyssen P, Mabery E, Boddeker N, Vrancken R, Froeyen M, Ansari IH, Dutartre H, Rozenski J, Gil LH, Letellier C, Lanford R, Canard B, Koenen F, Kerkhofs P, Donis RO, Herdewijn P, Watson J, De Clercq E, Puerstinger G, Neyts J. Paeshuyse J, et al. Among authors: canard b. J Virol. 2006 Jan;80(1):149-60. doi: 10.1128/JVI.80.1.149-160.2006. J Virol. 2006. PMID: 16352539 Free PMC article.
Preliminary crystallographic characterization of an RNA helicase from Kunjin virus.
Mastrangelo E, Bollati M, Milani M, Brisbarre N, de Lamballerie X, Coutard B, Canard B, Khromykh A, Bolognesi M. Mastrangelo E, et al. Among authors: canard b. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Sep 1;62(Pt 9):876-9. doi: 10.1107/S1744309106028776. Epub 2006 Aug 11. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006. PMID: 16946468 Free PMC article.
A second, non-canonical RNA-dependent RNA polymerase in SARS coronavirus.
Imbert I, Guillemot JC, Bourhis JM, Bussetta C, Coutard B, Egloff MP, Ferron F, Gorbalenya AE, Canard B. Imbert I, et al. Among authors: canard b. EMBO J. 2006 Oct 18;25(20):4933-42. doi: 10.1038/sj.emboj.7601368. Epub 2006 Oct 5. EMBO J. 2006. PMID: 17024178 Free PMC article.
283 results