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The thiazolobenzimidazole TBZE-029 inhibits enterovirus replication by targeting a short region immediately downstream from motif C in the nonstructural protein 2C.
De Palma AM, Heggermont W, Lanke K, Coutard B, Bergmann M, Monforte AM, Canard B, De Clercq E, Chimirri A, Pürstinger G, Rohayem J, van Kuppeveld F, Neyts J. De Palma AM, et al. Among authors: heggermont w. J Virol. 2008 May;82(10):4720-30. doi: 10.1128/JVI.01338-07. Epub 2008 Mar 12. J Virol. 2008. PMID: 18337578 Free PMC article.
Anti-enterovirus activity and structure-activity relationship of a series of 2,6-dihalophenyl-substituted 1H,3H-thiazolo[3,4-a]benzimidazoles.
De Palma AM, Heggermont W, Leyssen P, Pürstinger G, Wimmer E, De Clercq E, Rao A, Monforte AM, Chimirri A, Neyts J. De Palma AM, et al. Among authors: heggermont w. Biochem Biophys Res Commun. 2007 Feb 16;353(3):628-32. doi: 10.1016/j.bbrc.2006.12.063. Epub 2006 Dec 19. Biochem Biophys Res Commun. 2007. PMID: 17194441
Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307.
De Palma AM, Thibaut HJ, van der Linden L, Lanke K, Heggermont W, Ireland S, Andrews R, Arimilli M, Al-Tel TH, De Clercq E, van Kuppeveld F, Neyts J. De Palma AM, et al. Among authors: heggermont w. Antimicrob Agents Chemother. 2009 May;53(5):1850-7. doi: 10.1128/AAC.00934-08. Epub 2009 Feb 23. Antimicrob Agents Chemother. 2009. PMID: 19237651 Free PMC article.
The microRNA-221/-222 cluster balances the antiviral and inflammatory response in viral myocarditis.
Corsten MF, Heggermont W, Papageorgiou AP, Deckx S, Tijsma A, Verhesen W, van Leeuwen R, Carai P, Thibaut HJ, Custers K, Summer G, Hazebroek M, Verheyen F, Neyts J, Schroen B, Heymans S. Corsten MF, et al. Among authors: heggermont w. Eur Heart J. 2015 Nov 7;36(42):2909-19. doi: 10.1093/eurheartj/ehv321. Epub 2015 Jul 22. Eur Heart J. 2015. PMID: 26206211
Fatty acid carbon is essential for dNTP synthesis in endothelial cells.
Schoors S, Bruning U, Missiaen R, Queiroz KC, Borgers G, Elia I, Zecchin A, Cantelmo AR, Christen S, Goveia J, Heggermont W, Goddé L, Vinckier S, Van Veldhoven PP, Eelen G, Schoonjans L, Gerhardt H, Dewerchin M, Baes M, De Bock K, Ghesquière B, Lunt SY, Fendt SM, Carmeliet P. Schoors S, et al. Among authors: heggermont w. Nature. 2015 Apr 9;520(7546):192-197. doi: 10.1038/nature14362. Epub 2015 Apr 1. Nature. 2015. PMID: 25830893 Free PMC article.
Inhibition of MicroRNA-146a and Overexpression of Its Target Dihydrolipoyl Succinyltransferase Protect Against Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction.
Heggermont WA, Papageorgiou AP, Quaegebeur A, Deckx S, Carai P, Verhesen W, Eelen G, Schoors S, van Leeuwen R, Alekseev S, Elzenaar I, Vinckier S, Pokreisz P, Walravens AS, Gijsbers R, Van Den Haute C, Nickel A, Schroen B, van Bilsen M, Janssens S, Maack C, Pinto Y, Carmeliet P, Heymans S. Heggermont WA, et al. Circulation. 2017 Aug 22;136(8):747-761. doi: 10.1161/CIRCULATIONAHA.116.024171. Epub 2017 Jun 13. Circulation. 2017. PMID: 28611091
Osteoglycin prevents the development of age-related diastolic dysfunction during pressure overload by reducing cardiac fibrosis and inflammation.
Deckx S, Heggermont W, Carai P, Rienks M, Dresselaers T, Himmelreich U, van Leeuwen R, Lommen W, van der Velden J, Gonzalez A, Diez J, Papageorgiou AP, Heymans S. Deckx S, et al. Among authors: heggermont w. Matrix Biol. 2018 Mar;66:110-124. doi: 10.1016/j.matbio.2017.09.002. Epub 2017 Sep 25. Matrix Biol. 2018. PMID: 28958774
NF-κB-mediated metabolic remodelling in the inflamed heart in acute viral myocarditis.
Remels AHV, Derks WJA, Cillero-Pastor B, Verhees KJP, Kelders MC, Heggermont W, Carai P, Summer G, Ellis SR, de Theije CC, Heeren RMA, Heymans S, Papageorgiou AP, van Bilsen M. Remels AHV, et al. Among authors: heggermont w. Biochim Biophys Acta Mol Basis Dis. 2018 Aug;1864(8):2579-2589. doi: 10.1016/j.bbadis.2018.04.022. Epub 2018 May 3. Biochim Biophys Acta Mol Basis Dis. 2018. PMID: 29730342 Free article.
71 results