McLaughlin LA - Search Results

1

Characterization of inhibitors and substrates of Anopheles gambiae CYP6Z2.

McLaughlin LA, Niazi U, Bibby J, David JP, Vontas J, Hemingway J, Ranson H, Sutcliffe MJ, Paine MJ. McLaughlin LA, et al. Insect Mol Biol. 2008 Apr;17(2):125-35. doi: 10.1111/j.1365-2583.2007.00788.x. Insect Mol Biol. 2008. PMID: 18353102

2

Anopheles gambiae P450 reductase is highly expressed in oenocytes and in vivo knockdown increases permethrin susceptibility.

Lycett GJ, McLaughlin LA, Ranson H, Hemingway J, Kafatos FC, Loukeris TG, Paine MJ. Lycett GJ, et al. Among authors: mclaughlin la. Insect Mol Biol. 2006 Jun;15(3):321-7. doi: 10.1111/j.1365-2583.2006.00647.x. Insect Mol Biol. 2006. PMID: 16756551

3

Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.

Paine MJ, McLaughlin LA, Flanagan JU, Kemp CA, Sutcliffe MJ, Roberts GC, Wolf CR. Paine MJ, et al. Among authors: mclaughlin la. J Biol Chem. 2003 Feb 7;278(6):4021-7. doi: 10.1074/jbc.M209519200. Epub 2002 Nov 22. J Biol Chem. 2003. PMID: 12446689 Free article.

4

Role of conserved Asp293 of cytochrome P450 2C9 in substrate recognition and catalytic activity.

Flanagan JU, McLaughlin LA, Paine MJ, Sutcliffe MJ, Roberts GC, Wolf CR. Flanagan JU, et al. Among authors: mclaughlin la. Biochem J. 2003 Mar 15;370(Pt 3):921-6. doi: 10.1042/BJ20021841. Biochem J. 2003. PMID: 12482324 Free PMC article.

5

Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.

Flanagan JU, Maréchal JD, Ward R, Kemp CA, McLaughlin LA, Sutcliffe MJ, Roberts GC, Paine MJ, Wolf CR. Flanagan JU, et al. Among authors: mclaughlin la. Biochem J. 2004 Jun 1;380(Pt 2):353-60. doi: 10.1042/BJ20040062. Biochem J. 2004. PMID: 14992686 Free PMC article.

6

Biochemical comparison of Anopheles gambiae and human NADPH P450 reductases reveals different 2'-5'-ADP and FMN binding traits.

Lian LY, Widdowson P, McLaughlin LA, Paine MJ. Lian LY, et al. Among authors: mclaughlin la. PLoS One. 2011;6(5):e20574. doi: 10.1371/journal.pone.0020574. Epub 2011 May 31. PLoS One. 2011. PMID: 21655236 Free PMC article.

7

Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.

McLaughlin LA, Paine MJ, Kemp CA, Maréchal JD, Flanagan JU, Ward CJ, Sutcliffe MJ, Roberts GC, Wolf CR. McLaughlin LA, et al. J Biol Chem. 2005 Nov 18;280(46):38617-24. doi: 10.1074/jbc.M505974200. Epub 2005 Sep 14. J Biol Chem. 2005. PMID: 16162505 Free article.

8

Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.

McLaughlin LA, Dickmann LJ, Wolf CR, Henderson CJ. McLaughlin LA, et al. Drug Metab Dispos. 2008 Jul;36(7):1322-31. doi: 10.1124/dmd.108.021261. Epub 2008 Apr 17. Drug Metab Dispos. 2008. PMID: 18420780

9

Establishment of functional human cytochrome P450 monooxygenase systems in Escherichia coli.

Pritchard MP, McLaughlin L, Friedberg T. Pritchard MP, et al. Methods Mol Biol. 2006;320:19-29. doi: 10.1385/1-59259-998-2:19. Methods Mol Biol. 2006. PMID: 16719371

10

Evidence that cytochrome b5 and cytochrome b5 reductase can act as sole electron donors to the hepatic cytochrome P450 system.

Henderson CJ, McLaughlin LA, Wolf CR. Henderson CJ, et al. Among authors: mclaughlin la. Mol Pharmacol. 2013 Jun;83(6):1209-17. doi: 10.1124/mol.112.084616. Epub 2013 Mar 25. Mol Pharmacol. 2013. PMID: 23530090

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