Lipinski CA - Search Results

1

Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824.

Li X, Manjunatha UH, Goodwin MB, Knox JE, Lipinski CA, Keller TH, Barry CE 3rd, Dowd CS. Li X, et al. Among authors: lipinski ca. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2256-62. doi: 10.1016/j.bmcl.2008.03.011. Epub 2008 Mar 7. Bioorg Med Chem Lett. 2008. PMID: 18358721 Free PMC article.

2

Hydantoin bioisosteres. In vivo active spiro hydroxy acetic acid aldose reductase inhibitors.

Lipinski CA, Aldinger CE, Beyer TA, Bordner J, Burdi DF, Bussolotti DL, Inskeep PB, Siegel TW. Lipinski CA, et al. J Med Chem. 1992 Jun 12;35(12):2169-77. doi: 10.1021/jm00090a004. J Med Chem. 1992. PMID: 1613744

3

Quantitative structure-activity relationships among macrolide antibacterial agents: in vitro and in vivo potency against Pasteurella multocida.

McFarland JW, Berger CM, Froshauer SA, Hayashi SF, Hecker SJ, Jaynes BH, Jefson MR, Kamicker BJ, Lipinski CA, Lundy KM, Reese CP, Vu CB. McFarland JW, et al. Among authors: lipinski ca. J Med Chem. 1997 Apr 25;40(9):1340-6. doi: 10.1021/jm960436i. J Med Chem. 1997. PMID: 9135031

4

Bronchodilator and antiulcer phenoxypyrimidinones.

Lipinski CA, Stam JG, Pereira JN, Ackerman NR, Hess HJ. Lipinski CA, et al. J Med Chem. 1980 Sep;23(9):1026-31. doi: 10.1021/jm00183a012. J Med Chem. 1980. PMID: 7411545

5

A unified approach to systematic isosteric substitution for acidic groups and application to NMDA antagonists related to 2-amino-7-phosphonoheptanoate.

Chenard BL, Lipinski CA, Dominy BW, Mena EE, Ronau RT, Butterfield GC, Marinovic LC, Pagnozzi M, Butler TW, Tsang T. Chenard BL, et al. Among authors: lipinski ca. J Med Chem. 1990 Mar;33(3):1077-83. doi: 10.1021/jm00165a030. J Med Chem. 1990. PMID: 2155321

6

Pseudosymmetry and bioisosterism in biaryl pyridyl competitive histamine H2-receptor antagonists.

Lipinski CA, LaMattina JL, Hohnke LA. Lipinski CA, et al. J Med Chem. 1985 Nov;28(11):1628-36. doi: 10.1021/jm00149a015. J Med Chem. 1985. PMID: 2866245

7

Medicinal chemistry of aldose reductase inhibitors.

Larson ER, Lipinski CA, Sarges R. Larson ER, et al. Among authors: lipinski ca. Med Res Rev. 1988 Apr-Jun;8(2):159-86. doi: 10.1002/med.2610080202. Med Res Rev. 1988. PMID: 3132580 Review. No abstract available.

8

Bioisosteric prototype design of biaryl imidazolyl and triazolyl competitive histamine H2-receptor antagonists.

Lipinski CA, LaMattina JL, Oates PJ. Lipinski CA, et al. J Med Chem. 1986 Nov;29(11):2154-63. doi: 10.1021/jm00161a005. J Med Chem. 1986. PMID: 2878075

9

Single-mode compound retrieval for QSAR, QSPR data sets, and batch mode exact structure searching.

Lipinski CA. Lipinski CA. J Pharm Sci. 2002 Dec;91(12):2470-2. doi: 10.1002/jps.10260. J Pharm Sci. 2002. PMID: 12434389 No abstract available.

10

Parallel worlds of public and commercial bioactive chemistry data.

Lipinski CA, Litterman NK, Southan C, Williams AJ, Clark AM, Ekins S. Lipinski CA, et al. J Med Chem. 2015 Mar 12;58(5):2068-76. doi: 10.1021/jm5011308. Epub 2014 Dec 4. J Med Chem. 2015. PMID: 25415348 Free PMC article.

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