Kharas MG - Search Results

1

KLF4 is a FOXO target gene that suppresses B cell proliferation.

Yusuf I, Kharas MG, Chen J, Peralta RQ, Maruniak A, Sareen P, Yang VW, Kaestner KH, Fruman DA. Yusuf I, et al. Among authors: kharas mg. Int Immunol. 2008 May;20(5):671-81. doi: 10.1093/intimm/dxn024. Epub 2008 Mar 28. Int Immunol. 2008. PMID: 18375530

2

Phosphoinositide 3-kinase signaling is essential for ABL oncogene-mediated transformation of B-lineage cells.

Kharas MG, Deane JA, Wong S, O'Bosky KR, Rosenberg N, Witte ON, Fruman DA. Kharas MG, et al. Blood. 2004 Jun 1;103(11):4268-75. doi: 10.1182/blood-2003-07-2193. Epub 2004 Feb 19. Blood. 2004. PMID: 14976048 Free article.

3

Optimal B-cell proliferation requires phosphoinositide 3-kinase-dependent inactivation of FOXO transcription factors.

Yusuf I, Zhu X, Kharas MG, Chen J, Fruman DA. Yusuf I, et al. Among authors: kharas mg. Blood. 2004 Aug 1;104(3):784-7. doi: 10.1182/blood-2003-09-3071. Epub 2004 Apr 6. Blood. 2004. PMID: 15069012 Free article.

4

ABL oncogenes and phosphoinositide 3-kinase: mechanism of activation and downstream effectors.

Kharas MG, Fruman DA. Kharas MG, et al. Cancer Res. 2005 Mar 15;65(6):2047-53. doi: 10.1158/0008-5472.CAN-04-3888. Cancer Res. 2005. PMID: 15781610 Review.

5

S6 kinase 2 potentiates interleukin-3-driven cell proliferation.

Cruz R, Hedden L, Boyer D, Kharas MG, Fruman DA, Lee-Fruman KK. Cruz R, et al. Among authors: kharas mg. J Leukoc Biol. 2005 Dec;78(6):1378-85. doi: 10.1189/jlb.0405225. Epub 2005 Oct 4. J Leukoc Biol. 2005. PMID: 16204634 Free PMC article.

6

KLF4 suppresses transformation of pre-B cells by ABL oncogenes.

Kharas MG, Yusuf I, Scarfone VM, Yang VW, Segre JA, Huettner CS, Fruman DA. Kharas MG, et al. Blood. 2007 Jan 15;109(2):747-55. doi: 10.1182/blood-2006-03-011106. Epub 2006 Sep 5. Blood. 2007. PMID: 16954505 Free PMC article.

7

Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase.

Oak JS, Deane JA, Kharas MG, Luo J, Lane TE, Cantley LC, Fruman DA. Oak JS, et al. Among authors: kharas mg. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16882-7. doi: 10.1073/pnas.0607984103. Epub 2006 Oct 27. Proc Natl Acad Sci U S A. 2006. PMID: 17071741 Free PMC article.

8

T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling.

Deane JA, Kharas MG, Oak JS, Stiles LN, Luo J, Moore TI, Ji H, Rommel C, Cantley LC, Lane TE, Fruman DA. Deane JA, et al. Among authors: kharas mg. Blood. 2007 Apr 1;109(7):2894-902. doi: 10.1182/blood-2006-07-038620. Blood. 2007. PMID: 17164340 Free PMC article.

9

Measuring phosphorylated Akt and other phosphoinositide 3-kinase-regulated phosphoproteins in primary lymphocytes.

Donahue AC, Kharas MG, Fruman DA. Donahue AC, et al. Among authors: kharas mg. Methods Enzymol. 2007;434:131-54. doi: 10.1016/S0076-6879(07)34008-1. Methods Enzymol. 2007. PMID: 17954246

10

Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells.

Kharas MG, Janes MR, Scarfone VM, Lilly MB, Knight ZA, Shokat KM, Fruman DA. Kharas MG, et al. J Clin Invest. 2008 Sep;118(9):3038-50. doi: 10.1172/JCI33337. J Clin Invest. 2008. PMID: 18704194 Free PMC article.

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