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Page 1
Computational toxicology in drug development.
Muster W, Breidenbach A, Fischer H, Kirchner S, Müller L, Pähler A. Muster W, et al. Among authors: kirchner s. Drug Discov Today. 2008 Apr;13(7-8):303-10. doi: 10.1016/j.drudis.2007.12.007. Epub 2008 Feb 20. Drug Discov Today. 2008. PMID: 18405842 Review.
The photomutagenicity of fluoroquinolones and other drugs.
Gocke E, Albertini S, Chételat AA, Kirchner S, Muster W. Gocke E, et al. Among authors: kirchner s. Toxicol Lett. 1998 Dec 28;102-103:375-81. doi: 10.1016/s0378-4274(98)00235-5. Toxicol Lett. 1998. PMID: 10022282 Review.
Phototoxicity and photogenotoxicity of nine pyridone derivatives.
Gocke E, Chételat AA, Csato M, McGarvey DJ, Jakob-Roetne R, Kirchner S, Muster W, Potthast M, Widmer U. Gocke E, et al. Among authors: kirchner s. Mutat Res. 2003 Feb 5;535(1):43-54. doi: 10.1016/s1383-5718(02)00283-8. Mutat Res. 2003. PMID: 12547282
Specific Correction of Alternative Survival Motor Neuron 2 Splicing by Small Molecules: Discovery of a Potential Novel Medicine To Treat Spinal Muscular Atrophy.
Ratni H, Karp GM, Weetall M, Naryshkin NA, Paushkin SV, Chen KS, McCarthy KD, Qi H, Turpoff A, Woll MG, Zhang X, Zhang N, Yang T, Dakka A, Vazirani P, Zhao X, Pinard E, Green L, David-Pierson P, Tuerck D, Poirier A, Muster W, Kirchner S, Mueller L, Gerlach I, Metzger F. Ratni H, et al. Among authors: kirchner s. J Med Chem. 2016 Jul 14;59(13):6086-100. doi: 10.1021/acs.jmedchem.6b00459. Epub 2016 Jul 6. J Med Chem. 2016. PMID: 27299419
Mouse lymphoma thymidine kinase gene mutation assay: follow-up International Workshop on Genotoxicity Test Procedures, New Orleans, Louisiana, April 2000.
Moore MM, Honma M, Clements J, Harrington-Brock K, Awogi T, Bolcsfoldi G, Cifone M, Collard D, Fellows M, Flanders K, Gollapudi B, Jenkinson P, Kirby P, Kirchner S, Kraycer J, McEnaney S, Muster W, Myhr B, O'Donovan M, Oliver J, Ouldelhkim MC, Pant K, Preston R, Riach C, San R, Shimada H, Stankowski LF Jr. Moore MM, et al. Among authors: kirchner s. Environ Mol Mutagen. 2002;40(4):292-9. doi: 10.1002/em.10122. Environ Mol Mutagen. 2002. PMID: 12489120
How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop.
Kirkland D, Pfuhler S, Tweats D, Aardema M, Corvi R, Darroudi F, Elhajouji A, Glatt H, Hastwell P, Hayashi M, Kasper P, Kirchner S, Lynch A, Marzin D, Maurici D, Meunier JR, Müller L, Nohynek G, Parry J, Parry E, Thybaud V, Tice R, van Benthem J, Vanparys P, White P. Kirkland D, et al. Among authors: kirchner s. Mutat Res. 2007 Mar 30;628(1):31-55. doi: 10.1016/j.mrgentox.2006.11.008. Epub 2007 Jan 13. Mutat Res. 2007. PMID: 17293159
Mouse lymphoma thymidine kinase gene mutation assay: International Workshop on Genotoxicity Tests Workgroup report--Plymouth, UK 2002.
Moore MM, Honma M, Clements J, Bolcsfoldi G, Cifone M, Delongchamp R, Fellows M, Gollapudi B, Jenkinson P, Kirby P, Kirchner S, Muster W, Myhr B, O'Donovan M, Oliver J, Omori T, Ouldelhkim MC, Pant K, Preston R, Riach C, San R, Stankowski LF Jr, Thakur A, Wakuri S, Yoshimura I; Mouse Lymphoma Assay Workgroup. Moore MM, et al. Among authors: kirchner s. Mutat Res. 2003 Oct 7;540(2):127-40. doi: 10.1016/j.mrgentox.2003.07.003. Mutat Res. 2003. PMID: 14550497
Using ovality to predict nonmutagenic, orally efficacious pyridazine amides as cell specific spleen tyrosine kinase inhibitors.
Lucas MC, Bhagirath N, Chiao E, Goldstein DM, Hermann JC, Hsu PY, Kirchner S, Kennedy-Smith JJ, Kuglstatter A, Lukacs C, Menke J, Niu L, Padilla F, Peng Y, Polonchuk L, Railkar A, Slade M, Soth M, Xu D, Yadava P, Yee C, Zhou M, Liao C. Lucas MC, et al. Among authors: kirchner s. J Med Chem. 2014 Mar 27;57(6):2683-91. doi: 10.1021/jm401982j. Epub 2014 Feb 26. J Med Chem. 2014. PMID: 24520947
268 results