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Page 1
Activation of ErbB3, EGFR and Erk is essential for growth of human breast cancer cell lines with acquired resistance to fulvestrant.
Frogne T, Benjaminsen RV, Sonne-Hansen K, Sorensen BS, Nexo E, Laenkholm AV, Rasmussen LM, Riese DJ 2nd, de Cremoux P, Stenvang J, Lykkesfeldt AE. Frogne T, et al. Breast Cancer Res Treat. 2009 Mar;114(2):263-75. doi: 10.1007/s10549-008-0011-8. Epub 2008 Apr 14. Breast Cancer Res Treat. 2009. PMID: 18409071 Free PMC article.
Breast cancer cells can switch between estrogen receptor alpha and ErbB signaling and combined treatment against both signaling pathways postpones development of resistance.
Sonne-Hansen K, Norrie IC, Emdal KB, Benjaminsen RV, Frogne T, Christiansen IJ, Kirkegaard T, Lykkesfeldt AE. Sonne-Hansen K, et al. Among authors: frogne t. Breast Cancer Res Treat. 2010 Jun;121(3):601-13. doi: 10.1007/s10549-009-0506-y. Epub 2009 Aug 21. Breast Cancer Res Treat. 2010. PMID: 19697122
An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation.
Casteels T, Zhang Y, Frogne T, Sturtzel C, Lardeau CH, Sen I, Liu X, Hong S, Pauler FM, Penz T, Brandstetter M, Barbieux C, Berishvili E, Heuser T, Bock C, Riedel CG, Meyer D, Distel M, Hecksher-Sørensen J, Li J, Kubicek S. Casteels T, et al. Among authors: frogne t. Mol Metab. 2021 Dec;54:101329. doi: 10.1016/j.molmet.2021.101329. Epub 2021 Aug 25. Mol Metab. 2021. PMID: 34454092 Free PMC article.
The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates.
Tsonkova VG, Sand FW, Wolf XA, Grunnet LG, Kirstine Ringgaard A, Ingvorsen C, Winkel L, Kalisz M, Dalgaard K, Bruun C, Fels JJ, Helgstrand C, Hastrup S, Öberg FK, Vernet E, Sandrini MPB, Shaw AC, Jessen C, Grønborg M, Hald J, Willenbrock H, Madsen D, Wernersson R, Hansson L, Jensen JN, Plesner A, Alanentalo T, Petersen MBK, Grapin-Botton A, Honoré C, Ahnfelt-Rønne J, Hecksher-Sørensen J, Ravassard P, Madsen OD, Rescan C, Frogne T. Tsonkova VG, et al. Among authors: frogne t. Mol Metab. 2018 Feb;8:144-157. doi: 10.1016/j.molmet.2017.12.007. Epub 2017 Dec 19. Mol Metab. 2018. PMID: 29307512 Free PMC article.
MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes.
Ardestani A, Paroni F, Azizi Z, Kaur S, Khobragade V, Yuan T, Frogne T, Tao W, Oberholzer J, Pattou F, Conte JK, Maedler K. Ardestani A, et al. Among authors: frogne t. Nat Med. 2014 Apr;20(4):385-397. doi: 10.1038/nm.3482. Epub 2014 Mar 16. Nat Med. 2014. PMID: 24633305 Free PMC article.
Analysis artefacts of the INS-IGF2 fusion transcript.
Wernersson R, Frogne T, Rescan C, Hansson L, Bruun C, Grønborg M, Jensen JN, Madsen OD. Wernersson R, et al. Among authors: frogne t. BMC Mol Biol. 2015 Jul 29;16:13. doi: 10.1186/s12867-015-0042-8. BMC Mol Biol. 2015. PMID: 26220792 Free PMC article.
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