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Page 1
TGF-β signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling.
Cooley BC, Nevado J, Mellad J, Yang D, St Hilaire C, Negro A, Fang F, Chen G, San H, Walts AD, Schwartzbeck RL, Taylor B, Lanzer JD, Wragg A, Elagha A, Beltran LE, Berry C, Feil R, Virmani R, Ladich E, Kovacic JC, Boehm M. Cooley BC, et al. Sci Transl Med. 2014 Mar 12;6(227):227ra34. doi: 10.1126/scitranslmed.3006927. Sci Transl Med. 2014. PMID: 24622514 Free PMC article.
Stable transfection of MSCs by electroporation.
Peister A, Mellad JA, Wang M, Tucker HA, Prockop DJ. Peister A, et al. Among authors: mellad ja. Gene Ther. 2004 Jan;11(2):224-8. doi: 10.1038/sj.gt.3302163. Gene Ther. 2004. PMID: 14712307
Mammalian microtubule P-body dynamics are mediated by nesprin-1.
Rajgor D, Mellad JA, Soong D, Rattner JB, Fritzler MJ, Shanahan CM. Rajgor D, et al. Among authors: mellad ja. J Cell Biol. 2014 May 26;205(4):457-75. doi: 10.1083/jcb.201306076. J Cell Biol. 2014. PMID: 24862572 Free PMC article.
Nesprins LINC the nucleus and cytoskeleton.
Mellad JA, Warren DT, Shanahan CM. Mellad JA, et al. Curr Opin Cell Biol. 2011 Feb;23(1):47-54. doi: 10.1016/j.ceb.2010.11.006. Epub 2010 Dec 20. Curr Opin Cell Biol. 2011. PMID: 21177090 Review.
Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity.
Zhang Q, Bethmann C, Worth NF, Davies JD, Wasner C, Feuer A, Ragnauth CD, Yi Q, Mellad JA, Warren DT, Wheeler MA, Ellis JA, Skepper JN, Vorgerd M, Schlotter-Weigel B, Weissberg PL, Roberts RG, Wehnert M, Shanahan CM. Zhang Q, et al. Among authors: mellad ja. Hum Mol Genet. 2007 Dec 1;16(23):2816-33. doi: 10.1093/hmg/ddm238. Epub 2007 Aug 29. Hum Mol Genet. 2007. PMID: 17761684