Thomas CM - Search Results

1

In vivo mutational analysis of the mupirocin gene cluster reveals labile points in the biosynthetic pathway: the "leaky hosepipe" mechanism.

Wu J, Hothersall J, Mazzetti C, O'Connell Y, Shields JA, Rahman AS, Cox RJ, Crosby J, Simpson TJ, Thomas CM, Willis CL. Wu J, et al. Among authors: thomas cm. Chembiochem. 2008 Jun 16;9(9):1500-8. doi: 10.1002/cbic.200800085. Chembiochem. 2008. PMID: 18465759

2

Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster.

Cooper SM, Cox RJ, Crosby J, Crump MP, Hothersall J, Laosripaiboon W, Simpson TJ, Thomas CM. Cooper SM, et al. Among authors: thomas cm. Chem Commun (Camb). 2005 Mar 7;(9):1179-81. doi: 10.1039/b414781b. Epub 2005 Jan 17. Chem Commun (Camb). 2005. PMID: 15726184

3

Mupirocin H, a novel metabolite resulting from mutation of the HMG-CoA synthase analogue, mupH in Pseudomonas fluorescens.

Wu J, Cooper SM, Cox RJ, Crosby J, Crump MP, Hothersall J, Simpson TJ, Thomas CM, Willis CL. Wu J, et al. Among authors: thomas cm. Chem Commun (Camb). 2007 May 28;(20):2040-2. doi: 10.1039/b700613f. Chem Commun (Camb). 2007. PMID: 17713071

4

Phosphopantetheinylation and specificity of acyl carrier proteins in the mupirocin biosynthetic cluster.

Shields JA, Rahman AS, Arthur CJ, Crosby J, Hothersall J, Simpson TJ, Thomas CM. Shields JA, et al. Among authors: thomas cm. Chembiochem. 2010 Jan 25;11(2):248-55. doi: 10.1002/cbic.200900565. Chembiochem. 2010. PMID: 20013982

5

A conserved motif flags acyl carrier proteins for β-branching in polyketide synthesis.

Haines AS, Dong X, Song Z, Farmer R, Williams C, Hothersall J, Płoskoń E, Wattana-Amorn P, Stephens ER, Yamada E, Gurney R, Takebayashi Y, Masschelein J, Cox RJ, Lavigne R, Willis CL, Simpson TJ, Crosby J, Winn PJ, Thomas CM, Crump MP. Haines AS, et al. Among authors: thomas cm. Nat Chem Biol. 2013 Nov;9(11):685-692. doi: 10.1038/nchembio.1342. Epub 2013 Sep 22. Nat Chem Biol. 2013. PMID: 24056399 Free PMC article.

6

Biosynthesis of mupirocin by Pseudomonas fluorescens NCIMB 10586 involves parallel pathways.

Gao SS, Hothersall J, Wu J, Murphy AC, Song Z, Stephens ER, Thomas CM, Crump MP, Cox RJ, Simpson TJ, Willis CL. Gao SS, et al. Among authors: thomas cm. J Am Chem Soc. 2014 Apr 9;136(14):5501-7. doi: 10.1021/ja501731p. Epub 2014 Mar 27. J Am Chem Soc. 2014. PMID: 24625190

7

Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics.

Gao SS, Wang L, Song Z, Hothersall J, Stevens ER, Connolly J, Winn PJ, Cox RJ, Crump MP, Race PR, Thomas CM, Simpson TJ, Willis CL. Gao SS, et al. Among authors: thomas cm. Angew Chem Int Ed Engl. 2017 Mar 27;56(14):3930-3934. doi: 10.1002/anie.201611590. Epub 2017 Feb 9. Angew Chem Int Ed Engl. 2017. PMID: 28181382

8

Fine Tuning of Antibiotic Activity by a Tailoring Hydroxylase in a Trans-AT Polyketide Synthase Pathway.

Mohammad HH, Connolly JA, Song Z, Hothersall J, Race PR, Willis CL, Simpson TJ, Winn PJ, Thomas CM. Mohammad HH, et al. Among authors: thomas cm. Chembiochem. 2018 Apr 16;19(8):836-841. doi: 10.1002/cbic.201800036. Epub 2018 Mar 13. Chembiochem. 2018. PMID: 29363252

9

Characterization of the mupirocin biosynthesis gene cluster from Pseudomonas fluorescens NCIMB 10586.

El-Sayed AK, Hothersall J, Cooper SM, Stephens E, Simpson TJ, Thomas CM. El-Sayed AK, et al. Among authors: thomas cm. Chem Biol. 2003 May;10(5):419-30. doi: 10.1016/s1074-5521(03)00091-7. Chem Biol. 2003. PMID: 12770824

10

Tandemly duplicated acyl carrier proteins, which increase polyketide antibiotic production, can apparently function either in parallel or in series.

Rahman AS, Hothersall J, Crosby J, Simpson TJ, Thomas CM. Rahman AS, et al. Among authors: thomas cm. J Biol Chem. 2005 Feb 25;280(8):6399-408. doi: 10.1074/jbc.M409814200. Epub 2004 Dec 6. J Biol Chem. 2005. PMID: 15583005 Free article.

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