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Page 1
IRAK-4 inhibitors. Part 1: a series of amides.
Buckley GM, Gowers L, Higueruelo AP, Jenkins K, Mack SR, Morgan T, Parry DM, Pitt WR, Rausch O, Richard MD, Sabin V, Fraser JL. Buckley GM, et al. Among authors: gowers l. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3211-4. doi: 10.1016/j.bmcl.2008.04.058. Epub 2008 Apr 26. Bioorg Med Chem Lett. 2008. PMID: 18474425
7-Methoxyfuro[2,3-c]pyridine-4-carboxamides as PDE4 inhibitors: a potential treatment for asthma.
Buckley GM, Cooper N, Davenport RJ, Dyke HJ, Galleway FP, Gowers L, Haughan AF, Kendall HJ, Lowe C, Montana JG, Oxford J, Peake JC, Picken CL, Richard MD, Sabin V, Sharpe A, Warneck JB. Buckley GM, et al. Among authors: gowers l. Bioorg Med Chem Lett. 2002 Feb 11;12(3):509-12. doi: 10.1016/s0960-894x(01)00786-7. Bioorg Med Chem Lett. 2002. PMID: 11814830
8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: a potential treatment for asthma.
Buckley GM, Cooper N, Dyke HJ, Galleway FP, Gowers L, Haughan AF, Kendall HJ, Lowe C, Maxey R, Montana JG, Naylor R, Oxford J, Peake JC, Picken CL, Runcie KA, Sabin V, Sharpe A, Warneck JB. Buckley GM, et al. Among authors: gowers l. Bioorg Med Chem Lett. 2002 Jun 17;12(12):1613-5. doi: 10.1016/s0960-894x(02)00223-8. Bioorg Med Chem Lett. 2002. PMID: 12039574
A novel series of potent and selective IKK2 inhibitors.
Bingham AH, Davenport RJ, Gowers L, Knight RL, Lowe C, Owen DA, Parry DM, Pitt WR. Bingham AH, et al. Among authors: gowers l. Bioorg Med Chem Lett. 2004 Jan 19;14(2):409-12. doi: 10.1016/j.bmcl.2003.10.047. Bioorg Med Chem Lett. 2004. PMID: 14698170
Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors.
Alam M, Beevers RE, Ceska T, Davenport RJ, Dickson KM, Fortunato M, Gowers L, Haughan AF, James LA, Jones MW, Kinsella N, Lowe C, Meissner JW, Nicolas AL, Perry BG, Phillips DJ, Pitt WR, Platt A, Ratcliffe AJ, Sharpe A, Tait LJ. Alam M, et al. Among authors: gowers l. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3463-7. doi: 10.1016/j.bmcl.2007.03.078. Epub 2007 Mar 30. Bioorg Med Chem Lett. 2007. PMID: 17459703
IRAK-4 inhibitors. Part II: a structure-based assessment of imidazo[1,2-a]pyridine binding.
Buckley GM, Ceska TA, Fraser JL, Gowers L, Groom CR, Higueruelo AP, Jenkins K, Mack SR, Morgan T, Parry DM, Pitt WR, Rausch O, Richard MD, Sabin V. Buckley GM, et al. Among authors: gowers l. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3291-5. doi: 10.1016/j.bmcl.2008.04.039. Epub 2008 Apr 22. Bioorg Med Chem Lett. 2008. PMID: 18482836
IRAK-4 inhibitors. Part III: a series of imidazo[1,2-a]pyridines.
Buckley GM, Fosbeary R, Fraser JL, Gowers L, Higueruelo AP, James LA, Jenkins K, Mack SR, Morgan T, Parry DM, Pitt WR, Rausch O, Richard MD, Sabin V. Buckley GM, et al. Among authors: gowers l. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3656-60. doi: 10.1016/j.bmcl.2008.04.042. Epub 2008 Apr 24. Bioorg Med Chem Lett. 2008. PMID: 18501603
Achieving multi-isoform PI3K inhibition in a series of substituted 3,4-dihydro-2H-benzo[1,4]oxazines.
Perry B, Alexander R, Bennett G, Buckley G, Ceska T, Crabbe T, Dale V, Gowers L, Horsley H, James L, Jenkins K, Crépy K, Kulisa C, Lightfoot H, Lock C, Mack S, Morgan T, Nicolas AL, Pitt W, Sabin V, Wright S. Perry B, et al. Among authors: gowers l. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4700-4. doi: 10.1016/j.bmcl.2008.06.104. Epub 2008 Jul 5. Bioorg Med Chem Lett. 2008. PMID: 18644721
Optimization of a series of multi-isoform PI3 kinase inhibitors.
Perry B, Beevers R, Bennett G, Buckley G, Crabbe T, Gowers L, James L, Jenkins K, Lock C, Sabin V, Wright S. Perry B, et al. Among authors: gowers l. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5299-302. doi: 10.1016/j.bmcl.2008.08.042. Epub 2008 Aug 20. Bioorg Med Chem Lett. 2008. PMID: 18774713
24 results