Zurenko GE - Search Results

1

Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors.

Miller AA, Bundy GL, Mott JE, Skepner JE, Boyle TP, Harris DW, Hromockyj AE, Marotti KR, Zurenko GE, Munzner JB, Sweeney MT, Bammert GF, Hamel JC, Ford CW, Zhong WZ, Graber DR, Martin GE, Han F, Dolak LA, Seest EP, Ruble JC, Kamilar GM, Palmer JR, Banitt LS, Hurd AR, Barbachyn MR. Miller AA, et al. Among authors: zurenko ge. Antimicrob Agents Chemother. 2008 Aug;52(8):2806-12. doi: 10.1128/AAC.00247-08. Epub 2008 Jun 2. Antimicrob Agents Chemother. 2008. PMID: 18519725 Free PMC article.

2

In vitro activities of linezolid combined with other antimicrobial agents against Staphylococci, Enterococci, Pneumococci, and selected gram-negative organisms.

Sweeney MT, Zurenko GE. Sweeney MT, et al. Among authors: zurenko ge. Antimicrob Agents Chemother. 2003 Jun;47(6):1902-6. doi: 10.1128/AAC.47.6.1902-1906.2003. Antimicrob Agents Chemother. 2003. PMID: 12760865 Free PMC article.

3

Structure-activity relationships of bioisosteres of a carboxylic acid in a novel class of bacterial translation inhibitors.

Ruble JC, Wakefield BD, Kamilar GM, Marotti KR, Melchior E, Sweeney MT, Zurenko GE, Romero DL. Ruble JC, et al. Among authors: zurenko ge. Bioorg Med Chem Lett. 2007 Jul 15;17(14):4040-3. doi: 10.1016/j.bmcl.2007.04.074. Epub 2007 Apr 27. Bioorg Med Chem Lett. 2007. PMID: 17561394

4

Bacterial translation inhibitors, 1-acylindazol-3-ols as anthranilic acid mimics.

Stiff C, Graber DR, Thorarensen A, Wakefield BD, Marotti KR, Melchior EP, Sweeney MT, Han F, Rohrer DC, Zurenko GE, Romero DL. Stiff C, et al. Among authors: zurenko ge. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6293-7. doi: 10.1016/j.bmcl.2007.08.041. Epub 2007 Aug 25. Bioorg Med Chem Lett. 2008. PMID: 18951783

5

The discovery of linezolid, the first oxazolidinone antibacterial agent.

Ford CW, Zurenko GE, Barbachyn MR. Ford CW, et al. Among authors: zurenko ge. Curr Drug Targets Infect Disord. 2001 Aug;1(2):181-99. doi: 10.2174/1568005014606099. Curr Drug Targets Infect Disord. 2001. PMID: 12455414 Review.

6

Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens.

Barbachyn MR, Cleek GJ, Dolak LA, Garmon SA, Morris J, Seest EP, Thomas RC, Toops DS, Watt W, Wishka DG, Ford CW, Zurenko GE, Hamel JC, Schaadt RD, Stapert D, Yagi BH, Adams WJ, Friis JM, Slatter JG, Sams JP, Oien NL, Zaya MJ, Wienkers LC, Wynalda MA. Barbachyn MR, et al. Among authors: zurenko ge. J Med Chem. 2003 Jan 16;46(2):284-302. doi: 10.1021/jm020248u. J Med Chem. 2003. PMID: 12519066

7

Synthesis and biological evaluation of benzazepine oxazolidinone antibacterials.

Johnson PD, Aristoff PA, Zurenko GE, Schaadt RD, Yagi BH, Ford CW, Hamel JC, Stapert D, Moerman JK. Johnson PD, et al. Among authors: zurenko ge. Bioorg Med Chem Lett. 2003 Dec 1;13(23):4197-200. doi: 10.1016/j.bmcl.2003.07.017. Bioorg Med Chem Lett. 2003. PMID: 14623000

8

The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones.

Ciske FL, Barbachyn MR, Genin MJ, Grega KC, Lee CS, Dolak LA, Seest EP, Watt W, Adams WJ, Friis JM, Ford CW, Zurenko GE. Ciske FL, et al. Among authors: zurenko ge. Bioorg Med Chem Lett. 2003 Dec 1;13(23):4235-9. doi: 10.1016/j.bmcl.2003.07.029. Bioorg Med Chem Lett. 2003. PMID: 14623008

9

Preparation of novel antibacterial agents. Replacement of the central aromatic ring with heterocycles.

Li J, Wakefield BD, Ruble JC, Stiff CM, Romero DL, Marotti KR, Sweeney MT, Zurenko GE, Rohrer DC, Thorarensen A. Li J, et al. Among authors: zurenko ge. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2347-50. doi: 10.1016/j.bmcl.2006.12.055. Epub 2006 Dec 21. Bioorg Med Chem Lett. 2007. PMID: 17350254

10

Preparation of novel anthranilic acids as antibacterial agents. Extensive evaluation of alternative amide bioisosteres connecting the A- and the B-rings.

Thorarensen A, Wakefield BD, Romero DL, Marotti KR, Sweeney MT, Zurenko GE, Rohrer DC, Han F, Bryant GL Jr. Thorarensen A, et al. Among authors: zurenko ge. Bioorg Med Chem Lett. 2007 May 15;17(10):2823-7. doi: 10.1016/j.bmcl.2007.02.055. Epub 2007 Feb 25. Bioorg Med Chem Lett. 2007. PMID: 17368020

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