Christopher RJ - Search Results

1

Pharmacokinetic, pharmacodynamic, and efficacy profiles of alogliptin, a novel inhibitor of dipeptidyl peptidase-4, in rats, dogs, and monkeys.

Lee B, Shi L, Kassel DB, Asakawa T, Takeuchi K, Christopher RJ. Lee B, et al. Among authors: christopher rj. Eur J Pharmacol. 2008 Jul 28;589(1-3):306-14. doi: 10.1016/j.ejphar.2008.04.047. Epub 2008 Apr 26. Eur J Pharmacol. 2008. PMID: 18538760

2

Pharmacokinetics, pharmacodynamics, and tolerability of single increasing doses of the dipeptidyl peptidase-4 inhibitor alogliptin in healthy male subjects.

Christopher R, Covington P, Davenport M, Fleck P, Mekki QA, Wann ER, Karim A. Christopher R, et al. Clin Ther. 2008 Mar;30(3):513-27. doi: 10.1016/j.clinthera.2008.03.005. Clin Ther. 2008. PMID: 18405789 Clinical Trial.

3

Pharmacokinetics of alogliptin when administered with food, metformin, or cimetidine: a two-phase, crossover study in healthy subjects.

Karim A, Covington P, Christopher R, Davenport M, Fleck P, Li X, Wann E, Mekki Q. Karim A, et al. Int J Clin Pharmacol Ther. 2010 Jan;48(1):46-58. doi: 10.5414/cpp48046. Int J Clin Pharmacol Ther. 2010. PMID: 20040339 Clinical Trial.

4

Clinical pharmacology of alogliptin, a dipeptidyl peptidase-4 inhibitor, for the treatment of Type 2 diabetes.

Christopher R, Karim A. Christopher R, et al. Expert Rev Clin Pharmacol. 2009 Nov;2(6):589-600. doi: 10.1586/ecp.09.45. Expert Rev Clin Pharmacol. 2009. PMID: 22112254

5

Pharmacokinetic, pharmacodynamic, and tolerability profiles of the dipeptidyl peptidase-4 inhibitor alogliptin: a randomized, double-blind, placebo-controlled, multiple-dose study in adult patients with type 2 diabetes.

Covington P, Christopher R, Davenport M, Fleck P, Mekki QA, Wann ER, Karim A. Covington P, et al. Clin Ther. 2008 Mar;30(3):499-512. doi: 10.1016/j.clinthera.2008.03.004. Clin Ther. 2008. PMID: 18405788 Clinical Trial.

6

Single- and Multiple-dose Pharmacokinetics of a Lorcaserin Extended-release Tablet.

Christopher R, Morgan M, Ferry J, Rege B, Tang Y, Kristensen A, Shanahan W. Christopher R, et al. Clin Ther. 2016 Oct;38(10):2227-2238.e4. doi: 10.1016/j.clinthera.2016.08.016. Epub 2016 Sep 28. Clin Ther. 2016. PMID: 27692638 Free article. Clinical Trial.

7

Discovery and optimization of a highly efficacious class of 5-aryl-2-aminopyridines as FMS-like tyrosine kinase 3 (FLT3) inhibitors.

Liu G, Abraham S, Liu X, Xu S, Rooks AM, Nepomuceno R, Dao A, Brigham D, Gitnick D, Insko DE, Gardner MF, Zarrinkar PP, Christopher R, Belli B, Armstrong RC, Holladay MW. Liu G, et al. Bioorg Med Chem Lett. 2015 Sep 1;25(17):3436-41. doi: 10.1016/j.bmcl.2015.07.023. Epub 2015 Jul 14. Bioorg Med Chem Lett. 2015. PMID: 26208887

8

Pharmacokinetics and Tolerability of Lorcaserin in Special Populations: Elderly Patients and Patients with Renal or Hepatic Impairment.

Christopher RJ, Morgan ME, Tang Y, Anderson C, Sanchez M, Shanahan W. Christopher RJ, et al. Clin Ther. 2017 Apr;39(4):837-848.e7. doi: 10.1016/j.clinthera.2017.03.004. Epub 2017 Mar 30. Clin Ther. 2017. PMID: 28365033 Clinical Trial.

9

Modulation of sphingosine-1-phosphate in inflammatory bowel disease.

Peyrin-Biroulet L, Christopher R, Behan D, Lassen C. Peyrin-Biroulet L, et al. Autoimmun Rev. 2017 May;16(5):495-503. doi: 10.1016/j.autrev.2017.03.007. Epub 2017 Mar 7. Autoimmun Rev. 2017. PMID: 28279838 Review.

10

Discovery of APD371: Identification of a Highly Potent and Selective CB₂ Agonist for the Treatment of Chronic Pain.

Han S, Thoresen L, Jung JK, Zhu X, Thatte J, Solomon M, Gaidarov I, Unett DJ, Yoon WH, Barden J, Sadeque A, Usmani A, Chen C, Semple G, Grottick AJ, Al-Shamma H, Christopher R, Jones RM. Han S, et al. ACS Med Chem Lett. 2017 Nov 30;8(12):1309-1313. doi: 10.1021/acsmedchemlett.7b00396. eCollection 2017 Dec 14. ACS Med Chem Lett. 2017. PMID: 29259753 Free PMC article.

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