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Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases.
Ponce-Coria J, San-Cristobal P, Kahle KT, Vazquez N, Pacheco-Alvarez D, de Los Heros P, Juárez P, Muñoz E, Michel G, Bobadilla NA, Gimenez I, Lifton RP, Hebert SC, Gamba G. Ponce-Coria J, et al. Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8458-63. doi: 10.1073/pnas.0802966105. Epub 2008 Jun 11. Proc Natl Acad Sci U S A. 2008. PMID: 18550832 Free PMC article.
WNK4 kinase is a negative regulator of K+-Cl- cotransporters.
Garzón-Muvdi T, Pacheco-Alvarez D, Gagnon KB, Vázquez N, Ponce-Coria J, Moreno E, Delpire E, Gamba G. Garzón-Muvdi T, et al. Am J Physiol Renal Physiol. 2007 Apr;292(4):F1197-207. doi: 10.1152/ajprenal.00335.2006. Epub 2006 Dec 19. Am J Physiol Renal Physiol. 2007. PMID: 17182532 Free article.
Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway.
San-Cristobal P, Pacheco-Alvarez D, Richardson C, Ring AM, Vazquez N, Rafiqi FH, Chari D, Kahle KT, Leng Q, Bobadilla NA, Hebert SC, Alessi DR, Lifton RP, Gamba G. San-Cristobal P, et al. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4384-9. doi: 10.1073/pnas.0813238106. Epub 2009 Feb 24. Proc Natl Acad Sci U S A. 2009. PMID: 19240212 Free PMC article.
A single residue in transmembrane domain 11 defines the different affinity for thiazides between the mammalian and flounder NaCl transporters.
Castañeda-Bueno M, Vázquez N, Bustos-Jaimes I, Hernández D, Rodríguez-Lobato E, Pacheco-Alvarez D, Cariño-Cortés R, Moreno E, Bobadilla NA, Gamba G. Castañeda-Bueno M, et al. Am J Physiol Renal Physiol. 2010 Nov;299(5):F1111-9. doi: 10.1152/ajprenal.00412.2010. Epub 2010 Aug 18. Am J Physiol Renal Physiol. 2010. PMID: 20719978 Free PMC article.
WNK3 is a putative chloride-sensing kinase.
Pacheco-Alvarez D, Gamba G. Pacheco-Alvarez D, et al. Cell Physiol Biochem. 2011;28(6):1123-34. doi: 10.1159/000335848. Epub 2011 Dec 16. Cell Physiol Biochem. 2011. PMID: 22179001 Review.
WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.
Chávez-Canales M, Zhang C, Soukaseum C, Moreno E, Pacheco-Alvarez D, Vidal-Petiot E, Castañeda-Bueno M, Vázquez N, Rojas-Vega L, Meermeier NP, Rogers S, Jeunemaitre X, Yang CL, Ellison DH, Gamba G, Hadchouel J. Chávez-Canales M, et al. Among authors: pacheco alvarez d. Hypertension. 2014 Nov;64(5):1047-53. doi: 10.1161/HYPERTENSIONAHA.114.04036. Epub 2014 Aug 11. Hypertension. 2014. PMID: 25113964 Free PMC article.
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