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Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. A putative cellular mechanism for impaired protein kinase B activation and GLUT4 translocation.
Tirosh A, Potashnik R, Bashan N, Rudich A. Tirosh A, et al. J Biol Chem. 1999 Apr 9;274(15):10595-602. doi: 10.1074/jbc.274.15.10595. J Biol Chem. 1999. PMID: 10187855 Free article.
In a recent study we have demonstrated that 3T3-L1 adipocytes exposed to low micromolar H2O2 concentrations display impaired insulin stimulated GLUT4 translocation from internal membrane pools to the plasma membrane (Rudich, A., Tirosh, A., Potashnik, …
In a recent study we have demonstrated that 3T3-L1 adipocytes exposed to low micromolar H2O2 concentrations display impaired insulin …
Oxidative stress impairs insulin but not platelet-derived growth factor signalling in 3T3-L1 adipocytes.
Tirosh A, Rudich A, Potashnik R, Bashan N. Tirosh A, et al. Biochem J. 2001 May 1;355(Pt 3):757-63. doi: 10.1042/bj3550757. Biochem J. 2001. PMID: 11311139 Free PMC article.
Activation of phosphatidylinositol 3-kinase (PI 3-kinase) is a common event in both insulin and platelet-derived growth factor (PDGF) signalling, but only insulin activates this enzyme in the high-speed pellet (HSP), and induces GLUT4 translocation. Recently, we have demon …
Activation of phosphatidylinositol 3-kinase (PI 3-kinase) is a common event in both insulin and platelet-derived growth factor (PDGF) …
Normal fasting plasma glucose levels and type 2 diabetes in young men.
Tirosh A, Shai I, Tekes-Manova D, Israeli E, Pereg D, Shochat T, Kochba I, Rudich A; Israeli Diabetes Research Group. Tirosh A, et al. N Engl J Med. 2005 Oct 6;353(14):1454-62. doi: 10.1056/NEJMoa050080. N Engl J Med. 2005. PMID: 16207847 Free article.
Autoimmune diseases in asthma.
Tirosh A, Mandel D, Mimouni FB, Zimlichman E, Shochat T, Kochba I. Tirosh A, et al. Ann Intern Med. 2006 Jun 20;144(12):877-83. doi: 10.7326/0003-4819-144-12-200606200-00004. Ann Intern Med. 2006. PMID: 16785476
203 results