van Aalten DM - Search Results

1

Structural and kinetic differences between human and Aspergillus fumigatus D-glucosamine-6-phosphate N-acetyltransferase.

Hurtado-Guerrero R, Raimi OG, Min J, Zeng H, Vallius L, Shepherd S, Ibrahim AF, Wu H, Plotnikov AN, van Aalten DM. Hurtado-Guerrero R, et al. Among authors: van aalten dm. Biochem J. 2008 Oct 15;415(2):217-23. doi: 10.1042/BJ20081000. Biochem J. 2008. PMID: 18601654

2

Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity.

Thomas CC, Dowler S, Deak M, Alessi DR, van Aalten DM. Thomas CC, et al. Among authors: van aalten dm. Biochem J. 2001 Sep 1;358(Pt 2):287-94. doi: 10.1042/0264-6021:3580287. Biochem J. 2001. PMID: 11513726 Free PMC article.

3

The cyclic dipeptide CI-4 [cyclo-(l-Arg-d-Pro)] inhibits family 18 chitinases by structural mimicry of a reaction intermediate.

Houston DR, Eggleston I, Synstad B, Eijsink VG, van Aalten DM. Houston DR, et al. Among authors: van aalten dm. Biochem J. 2002 Nov 15;368(Pt 1):23-7. doi: 10.1042/BJ20021034. Biochem J. 2002. PMID: 12323074 Free PMC article.

4

Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition.

Komander D, Kular GS, Bain J, Elliott M, Alessi DR, Van Aalten DM. Komander D, et al. Among authors: van aalten dm. Biochem J. 2003 Oct 15;375(Pt 2):255-62. doi: 10.1042/BJ20031119. Biochem J. 2003. PMID: 12892559 Free PMC article.

5

Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change.

Milburn CC, Deak M, Kelly SM, Price NC, Alessi DR, Van Aalten DM. Milburn CC, et al. Among authors: van aalten dm. Biochem J. 2003 Nov 1;375(Pt 3):531-8. doi: 10.1042/BJ20031229. Biochem J. 2003. PMID: 12964941 Free PMC article.

6

Structures of Bacillus subtilis PdaA, a family 4 carbohydrate esterase, and a complex with N-acetyl-glucosamine.

Blair DE, van Aalten DM. Blair DE, et al. Among authors: van aalten dm. FEBS Lett. 2004 Jul 16;570(1-3):13-9. doi: 10.1016/j.febslet.2004.06.013. FEBS Lett. 2004. PMID: 15251431 Free article.

7

Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocket.

Villa F, Deak M, Bloomberg GB, Alessi DR, van Aalten DM. Villa F, et al. Among authors: van aalten dm. J Biol Chem. 2005 Mar 4;280(9):8180-7. doi: 10.1074/jbc.M412211200. Epub 2004 Dec 20. J Biol Chem. 2005. PMID: 15611135 Free article.

8

Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases.

Rao FV, Houston DR, Boot RG, Aerts JM, Hodkinson M, Adams DJ, Shiomi K, Omura S, van Aalten DM. Rao FV, et al. Among authors: van aalten dm. Chem Biol. 2005 Jan;12(1):65-76. doi: 10.1016/j.chembiol.2004.10.013. Chem Biol. 2005. PMID: 15664516

9

Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum, a key enzyme in fatty acid biosynthesis.

Wickramasinghe SR, Inglis KA, Urch JE, Müller S, van Aalten DM, Fairlamb AH. Wickramasinghe SR, et al. Among authors: van aalten dm. Biochem J. 2006 Jan 15;393(Pt 2):447-57. doi: 10.1042/BJ20050832. Biochem J. 2006. PMID: 16225460 Free PMC article.

10

The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation.

Jaleel M, Villa F, Deak M, Toth R, Prescott AR, Van Aalten DM, Alessi DR. Jaleel M, et al. Among authors: van aalten dm. Biochem J. 2006 Mar 15;394(Pt 3):545-55. doi: 10.1042/BJ20051844. Biochem J. 2006. PMID: 16396636 Free PMC article.

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