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Discovery of S-[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an orally bioavailable and highly selective inhibitor of p38 MAP kinase.
Goldstein DM, Alfredson T, Bertrand J, Browner MF, Clifford K, Dalrymple SA, Dunn J, Freire-Moar J, Harris S, Labadie SS, La Fargue J, Lapierre JM, Larrabee S, Li F, Papp E, McWeeney D, Ramesha C, Roberts R, Rotstein D, San Pablo B, Sjogren EB, So OY, Talamas FX, Tao W, Trejo A, Villasenor A, Welch M, Welch T, Weller P, Whiteley PE, Young K, Zipfel S. Goldstein DM, et al. Among authors: alfredson t. J Med Chem. 2006 Mar 9;49(5):1562-75. doi: 10.1021/jm050736c. J Med Chem. 2006. PMID: 16509574
Evaluation of polyethylene oxide compacts as gastroretentive delivery systems.
Mahalingam R, Jasti B, Birudaraj R, Stefanidis D, Killion R, Alfredson T, Anne P, Li X. Mahalingam R, et al. Among authors: alfredson t. AAPS PharmSciTech. 2009;10(1):98-103. doi: 10.1208/s12249-008-9182-1. Epub 2009 Jan 16. AAPS PharmSciTech. 2009. PMID: 19148757 Free PMC article.
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