Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment.
Rangone H, Pardo R, Colin E, Girault JA, Saudou F, Humbert S.
Rangone H, et al. Among authors: humbert s.
J Biol Chem. 2005 Jun 10;280(23):22021-8. doi: 10.1074/jbc.M407528200. Epub 2005 Apr 4.
J Biol Chem. 2005.
PMID: 15809304
Free article.
This neuroprotective effect involves the phosphorylation of huntingtin at Ser(421) by the prosurvival kinase Akt (Humbert, S., Bryson, E. A., Cordelieres, F. P., Connors, N. C., Datta, S. R., Finkbeiner, S., Greenberg, M. ...Here, we report that Akt in …
This neuroprotective effect involves the phosphorylation of huntingtin at Ser(421) by the prosurvival kinase Akt (Humbert, S., …