Hanrahan JR - Search Results

1

Flavan-3-ol derivatives are positive modulators of GABA(A) receptors with higher efficacy for the alpha(2) subtype and anxiolytic action in mice.

Fernandez SP, Mewett KN, Hanrahan JR, Chebib M, Johnston GA. Fernandez SP, et al. Among authors: hanrahan jr. Neuropharmacology. 2008 Oct;55(5):900-7. doi: 10.1016/j.neuropharm.2008.06.069. Epub 2008 Jul 9. Neuropharmacology. 2008. PMID: 18657554

2

Synthesis and activity of a potent N-methyl-D-aspartic acid agonist, trans-1-aminocyclobutane-1,3-dicarboxylic acid, and related phosphonic and carboxylic acids.

Allan RD, Hanrahan JR, Hambley TW, Johnston GA, Mewett KN, Mitrovic AD. Allan RD, et al. Among authors: hanrahan jr. J Med Chem. 1990 Oct;33(10):2905-15. doi: 10.1021/jm00172a036. J Med Chem. 1990. PMID: 2145435

3

Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors.

Hanrahan JR, Chebib M, Davucheron NL, Hall BJ, Johnston GA. Hanrahan JR, et al. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2281-4. doi: 10.1016/s0960-894x(03)00434-7. Bioorg Med Chem Lett. 2003. PMID: 12824018

4

GABA(C) receptors as drug targets.

Johnston GA, Chebib M, Hanrahan JR, Mewett KN. Johnston GA, et al. Among authors: hanrahan jr. Curr Drug Targets CNS Neurol Disord. 2003 Aug;2(4):260-8. doi: 10.2174/1568007033482805. Curr Drug Targets CNS Neurol Disord. 2003. PMID: 12871036 Review.

5

Mutations of the 2' proline in the M2 domain of the human GABAC rho1 subunit alter agonist responses.

Carland JE, Moore AM, Hanrahan JR, Mewett KN, Duke RK, Johnston GA, Chebib M. Carland JE, et al. Among authors: hanrahan jr. Neuropharmacology. 2004 May;46(6):770-81. doi: 10.1016/j.neuropharm.2003.11.027. Neuropharmacology. 2004. PMID: 15033337

6

Flumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptors.

Hall BJ, Chebib M, Hanrahan JR, Johnston GA. Hall BJ, et al. Among authors: hanrahan jr. Eur J Pharmacol. 2004 Apr 26;491(1):1-8. doi: 10.1016/j.ejphar.2004.03.014. Eur J Pharmacol. 2004. PMID: 15102527

7

6-Methylflavanone, a more efficacious positive allosteric modulator of gamma-aminobutyric acid (GABA) action at human recombinant alpha2beta2gamma2L than at alpha1beta2gamma2L and alpha1beta2 GABA(A) receptors expressed in Xenopus oocytes.

Hall BJ, Chebib M, Hanrahan JR, Johnston GA. Hall BJ, et al. Among authors: hanrahan jr. Eur J Pharmacol. 2005 Apr 11;512(2-3):97-104. doi: 10.1016/j.ejphar.2005.02.034. Eur J Pharmacol. 2005. PMID: 15840393

8

Diastereoselective synthesis of (+/-)-(3-aminocyclopentane)alkylphosphinic acids, conformationally restricted analogues of GABA.

Hanrahan JR, Mewett KN, Chebib M, Matos S, Eliopoulos CT, Crean C, Kumar RJ, Burden P, Johnston GA. Hanrahan JR, et al. Org Biomol Chem. 2006 Jul 7;4(13):2642-9. doi: 10.1039/b604002k. Epub 2006 Jun 1. Org Biomol Chem. 2006. PMID: 16791329

9

Stabilization of zwitterions in solution: phosphinic and phosphonic acid GABA analogues.

Crittenden DL, Kumar RJ, Hanrahan JR, Chebib M, Jordan MJ. Crittenden DL, et al. Among authors: hanrahan jr. J Phys Chem A. 2005 Sep 22;109(37):8398-409. doi: 10.1021/jp051227p. J Phys Chem A. 2005. PMID: 16834233

10

(3-Aminocyclopentyl)methylphosphinic acids: novel GABA(C) receptor antagonists.

Chebib M, Hanrahan JR, Kumar RJ, Mewett KN, Morriss G, Wooller S, Johnston GA. Chebib M, et al. Among authors: hanrahan jr. Neuropharmacology. 2007 Mar;52(3):779-87. doi: 10.1016/j.neuropharm.2006.09.014. Epub 2006 Nov 13. Neuropharmacology. 2007. PMID: 17098260

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