Bauer PO - Search Results

1

Blocking acid-sensing ion channel 1 alleviates Huntington's disease pathology via an ubiquitin-proteasome system-dependent mechanism.

Wong HK, Bauer PO, Kurosawa M, Goswami A, Washizu C, Machida Y, Tosaki A, Yamada M, Knöpfel T, Nakamura T, Nukina N. Wong HK, et al. Among authors: bauer po. Hum Mol Genet. 2008 Oct 15;17(20):3223-35. doi: 10.1093/hmg/ddn218. Epub 2008 Jul 24. Hum Mol Genet. 2008. PMID: 18658163

2

Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein.

Bauer PO, Goswami A, Wong HK, Okuno M, Kurosawa M, Yamada M, Miyazaki H, Matsumoto G, Kino Y, Nagai Y, Nukina N. Bauer PO, et al. Nat Biotechnol. 2010 Mar;28(3):256-63. doi: 10.1038/nbt.1608. Epub 2010 Feb 28. Nat Biotechnol. 2010. PMID: 20190739

3

Expanded polyglutamines impair synaptic transmission and ubiquitin-proteasome system in Caenorhabditis elegans.

Khan LA, Bauer PO, Miyazaki H, Lindenberg KS, Landwehrmeyer BG, Nukina N. Khan LA, et al. Among authors: bauer po. J Neurochem. 2006 Jul;98(2):576-87. doi: 10.1111/j.1471-4159.2006.03895.x. J Neurochem. 2006. PMID: 16805848 Free article.

4

RNA-binding protein TLS is a major nuclear aggregate-interacting protein in huntingtin exon 1 with expanded polyglutamine-expressing cells.

Doi H, Okamura K, Bauer PO, Furukawa Y, Shimizu H, Kurosawa M, Machida Y, Miyazaki H, Mitsui K, Kuroiwa Y, Nukina N. Doi H, et al. Among authors: bauer po. J Biol Chem. 2008 Mar 7;283(10):6489-500. doi: 10.1074/jbc.M705306200. Epub 2007 Dec 31. J Biol Chem. 2008. PMID: 18167354 Free article.

5

Inhibition of Rho kinases enhances the degradation of mutant huntingtin.

Bauer PO, Wong HK, Oyama F, Goswami A, Okuno M, Kino Y, Miyazaki H, Nukina N. Bauer PO, et al. J Biol Chem. 2009 May 8;284(19):13153-64. doi: 10.1074/jbc.M809229200. Epub 2009 Mar 11. J Biol Chem. 2009. PMID: 19278999 Free PMC article.

6

Enhanced degradation of mutant huntingtin by rho kinase inhibition is mediated through activation of proteasome and macroautophagy.

Bauer PO, Nukina N. Bauer PO, et al. Autophagy. 2009 Jul;5(5):747-8. doi: 10.4161/auto.5.5.8704. Epub 2009 Jul 9. Autophagy. 2009. PMID: 19411823

7

The pathogenic mechanisms of polyglutamine diseases and current therapeutic strategies.

Bauer PO, Nukina N. Bauer PO, et al. J Neurochem. 2009 Sep;110(6):1737-65. doi: 10.1111/j.1471-4159.2009.06302.x. Epub 2009 Jul 23. J Neurochem. 2009. PMID: 19650870 Free article. Review.

8

ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT.

Bauer PO, Hudec R, Goswami A, Kurosawa M, Matsumoto G, Mikoshiba K, Nukina N. Bauer PO, et al. Mol Neurodegener. 2012 Aug 28;7:43. doi: 10.1186/1750-1326-7-43. Mol Neurodegener. 2012. PMID: 22929228 Free PMC article.

9

Large-scale RNA interference screening in mammalian cells identifies novel regulators of mutant huntingtin aggregation.

Yamanaka T, Wong HK, Tosaki A, Bauer PO, Wada K, Kurosawa M, Shimogori T, Hattori N, Nukina N. Yamanaka T, et al. Among authors: bauer po. PLoS One. 2014 Apr 4;9(4):e93891. doi: 10.1371/journal.pone.0093891. eCollection 2014. PLoS One. 2014. PMID: 24705917 Free PMC article.

10

Genetic ablation and chemical inhibition of IP3R1 reduce mutant huntingtin aggregation.

Bauer PO, Hudec R, Ozaki S, Okuno M, Ebisui E, Mikoshiba K, Nukina N. Bauer PO, et al. Biochem Biophys Res Commun. 2011 Dec 9;416(1-2):13-7. doi: 10.1016/j.bbrc.2011.10.096. Epub 2011 Oct 28. Biochem Biophys Res Commun. 2011. PMID: 22056561

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