Hay S - Search Results

1

Solvent as a probe of active site motion and chemistry during the hydrogen tunnelling reaction in morphinone reductase.

Hay S, Pudney CR, Sutcliffe MJ, Scrutton NS. Hay S, et al. Chemphyschem. 2008 Sep 15;9(13):1875-81. doi: 10.1002/cphc.200800303. Chemphyschem. 2008. PMID: 18668493

2

Alpha-secondary isotope effects as probes of "tunneling-ready" configurations in enzymatic H-tunneling: insight from environmentally coupled tunneling models.

Pudney CR, Hay S, Sutcliffe MJ, Scrutton NS. Pudney CR, et al. Among authors: hay s. J Am Chem Soc. 2006 Nov 1;128(43):14053-8. doi: 10.1021/ja0614619. J Am Chem Soc. 2006. PMID: 17061887

3

Promoting motions in enzyme catalysis probed by pressure studies of kinetic isotope effects.

Hay S, Sutcliffe MJ, Scrutton NS. Hay S, et al. Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):507-12. doi: 10.1073/pnas.0608408104. Epub 2007 Jan 3. Proc Natl Acad Sci U S A. 2007. PMID: 17202258 Free PMC article.

4

Proton tunneling in aromatic amine dehydrogenase is driven by a short-range sub-picosecond promoting vibration: consistency of simulation and theory with experiment.

Johannissen LO, Hay S, Scrutton NS, Sutcliffe MJ. Johannissen LO, et al. Among authors: hay s. J Phys Chem B. 2007 Mar 15;111(10):2631-8. doi: 10.1021/jp066276w. Epub 2007 Feb 17. J Phys Chem B. 2007. PMID: 17305385

5

Conformational and thermodynamic control of electron transfer in neuronal nitric oxide synthase.

Dunford AJ, Rigby SE, Hay S, Munro AW, Scrutton NS. Dunford AJ, et al. Among authors: hay s. Biochemistry. 2007 May 1;46(17):5018-29. doi: 10.1021/bi7001339. Epub 2007 Apr 6. Biochemistry. 2007. PMID: 17411075

6

Conformational dynamics of the cytochrome P450 BM3/N-palmitoylglycine complex: the proposed "proximal-distal" transition probed by temperature-jump spectroscopy.

Brenner S, Hay S, Girvan HM, Munro AW, Scrutton NS. Brenner S, et al. Among authors: hay s. J Phys Chem B. 2007 Jul 12;111(27):7879-86. doi: 10.1021/jp073036n. Epub 2007 Jun 16. J Phys Chem B. 2007. PMID: 17571881

7

DNA binding suppresses human AIF-M2 activity and provides a connection between redox chemistry, reactive oxygen species, and apoptosis.

Gong M, Hay S, Marshall KR, Munro AW, Scrutton NS. Gong M, et al. Among authors: hay s. J Biol Chem. 2007 Oct 12;282(41):30331-40. doi: 10.1074/jbc.M703713200. Epub 2007 Aug 20. J Biol Chem. 2007. PMID: 17711848 Free article.

8

Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms.

Pudney CR, Hay S, Pang J, Costello C, Leys D, Sutcliffe MJ, Scrutton NS. Pudney CR, et al. Among authors: hay s. J Am Chem Soc. 2007 Nov 14;129(45):13949-56. doi: 10.1021/ja074463h. Epub 2007 Oct 16. J Am Chem Soc. 2007. PMID: 17939663

9

Magnetic field effect studies indicate reduced geminate recombination of the radical pair in substrate-bound adenosylcobalamin-dependent ethanolamine ammonia lyase.

Jones AR, Hay S, Woodward JR, Scrutton NS. Jones AR, et al. Among authors: hay s. J Am Chem Soc. 2007 Dec 19;129(50):15718-27. doi: 10.1021/ja077124x. Epub 2007 Nov 28. J Am Chem Soc. 2007. PMID: 18041840

10

Are environmentally coupled enzymatic hydrogen tunneling reactions influenced by changes in solution viscosity?

Hay S, Pudney CR, Sutcliffe MJ, Scrutton NS. Hay S, et al. Angew Chem Int Ed Engl. 2008;47(3):537-40. doi: 10.1002/anie.200704484. Angew Chem Int Ed Engl. 2008. PMID: 18058788 No abstract available.

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