Sutcliffe MJ - Search Results

1

Solvent as a probe of active site motion and chemistry during the hydrogen tunnelling reaction in morphinone reductase.

Hay S, Pudney CR, Sutcliffe MJ, Scrutton NS. Hay S, et al. Among authors: sutcliffe mj. Chemphyschem. 2008 Sep 15;9(13):1875-81. doi: 10.1002/cphc.200800303. Chemphyschem. 2008. PMID: 18668493

2

Computational studies of enzyme mechanism: linking theory with experiment in the analysis of enzymic H-tunnelling.

Sutcliffe MJ, Scrutton NS. Sutcliffe MJ, et al. Phys Chem Chem Phys. 2006 Oct 21;8(39):4510-6. doi: 10.1039/b609622k. Epub 2006 Aug 22. Phys Chem Chem Phys. 2006. PMID: 17047748

3

Alpha-secondary isotope effects as probes of "tunneling-ready" configurations in enzymatic H-tunneling: insight from environmentally coupled tunneling models.

Pudney CR, Hay S, Sutcliffe MJ, Scrutton NS. Pudney CR, et al. Among authors: sutcliffe mj. J Am Chem Soc. 2006 Nov 1;128(43):14053-8. doi: 10.1021/ja0614619. J Am Chem Soc. 2006. PMID: 17061887

4

Promoting motions in enzyme catalysis probed by pressure studies of kinetic isotope effects.

Hay S, Sutcliffe MJ, Scrutton NS. Hay S, et al. Among authors: sutcliffe mj. Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):507-12. doi: 10.1073/pnas.0608408104. Epub 2007 Jan 3. Proc Natl Acad Sci U S A. 2007. PMID: 17202258 Free PMC article.

5

Proton tunneling in aromatic amine dehydrogenase is driven by a short-range sub-picosecond promoting vibration: consistency of simulation and theory with experiment.

Johannissen LO, Hay S, Scrutton NS, Sutcliffe MJ. Johannissen LO, et al. Among authors: sutcliffe mj. J Phys Chem B. 2007 Mar 15;111(10):2631-8. doi: 10.1021/jp066276w. Epub 2007 Feb 17. J Phys Chem B. 2007. PMID: 17305385

6

Tunneling and classical paths for proton transfer in an enzyme reaction dominated by tunneling: oxidation of tryptamine by aromatic amine dehydrogenase.

Masgrau L, Ranaghan KE, Scrutton NS, Mulholland AJ, Sutcliffe MJ. Masgrau L, et al. Among authors: sutcliffe mj. J Phys Chem B. 2007 Mar 22;111(11):3032-47. doi: 10.1021/jp067898k. Epub 2007 Mar 1. J Phys Chem B. 2007. PMID: 17388439

7

Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms.

Pudney CR, Hay S, Pang J, Costello C, Leys D, Sutcliffe MJ, Scrutton NS. Pudney CR, et al. Among authors: sutcliffe mj. J Am Chem Soc. 2007 Nov 14;129(45):13949-56. doi: 10.1021/ja074463h. Epub 2007 Oct 16. J Am Chem Soc. 2007. PMID: 17939663

8

Are environmentally coupled enzymatic hydrogen tunneling reactions influenced by changes in solution viscosity?

Hay S, Pudney CR, Sutcliffe MJ, Scrutton NS. Hay S, et al. Among authors: sutcliffe mj. Angew Chem Int Ed Engl. 2008;47(3):537-40. doi: 10.1002/anie.200704484. Angew Chem Int Ed Engl. 2008. PMID: 18058788 No abstract available.

9

Atomistic insight into the origin of the temperature-dependence of kinetic isotope effects and H-tunnelling in enzyme systems is revealed through combined experimental studies and biomolecular simulation.

Hay S, Pudney C, Hothi P, Johannissen LO, Masgrau L, Pang J, Leys D, Sutcliffe MJ, Scrutton NS. Hay S, et al. Among authors: sutcliffe mj. Biochem Soc Trans. 2008 Feb;36(Pt 1):16-21. doi: 10.1042/BST0360016. Biochem Soc Trans. 2008. PMID: 18208377 Review.

10

Deep tunneling dominates the biologically important hydride transfer reaction from NADH to FMN in morphinone reductase.

Pang J, Hay S, Scrutton NS, Sutcliffe MJ. Pang J, et al. Among authors: sutcliffe mj. J Am Chem Soc. 2008 Jun 4;130(22):7092-7. doi: 10.1021/ja800471f. Epub 2008 May 10. J Am Chem Soc. 2008. PMID: 18470990

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