Himes RH - Search Results

1

Total synthesis and evaluation of C25-benzyloxyepothilone C for tubulin assembly and cytotoxicity against MCF-7 breast cancer cells.

Hutt OE, Reddy BS, Nair SK, Reiff EA, Henri JT, Greiner JF, Chiu TL, Vandervelde DG, Amin EA, Himes RH, Georg GI. Hutt OE, et al. Among authors: himes rh. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4904-6. doi: 10.1016/j.bmcl.2008.07.024. Epub 2008 Jul 11. Bioorg Med Chem Lett. 2008. PMID: 18684624 Free PMC article.

2

Cryptophycin affinity labels: synthesis and biological activity of a benzophenone analogue of cryptophycin-24.

Vidya R, Eggen M, Georg GI, Himes RH. Vidya R, et al. Among authors: himes rh. Bioorg Med Chem Lett. 2003 Feb 24;13(4):757-60. doi: 10.1016/s0960-894x(02)01023-5. Bioorg Med Chem Lett. 2003. PMID: 12639575

3

Total synthesis and antitubulin activity of c10 analogues of cryptophycin-24.

Buck SB, Huff JK, Himes RH, Georg GI. Buck SB, et al. Among authors: himes rh. J Med Chem. 2004 Jan 29;47(3):696-702. doi: 10.1021/jm030278c. J Med Chem. 2004. PMID: 14736249

4

Total synthesis and anti-tubulin activity of epi-c3 analogues of cryptophycin-24.

Buck SB, Huff JK, Himes RH, Georg GI. Buck SB, et al. Among authors: himes rh. J Med Chem. 2004 Jul 1;47(14):3697-9. doi: 10.1021/jm030555f. J Med Chem. 2004. PMID: 15214797

5

Synthesis and anti-tubulin activity of a 3'-(4-azidophenyl)-3'-dephenylpaclitaxel photoaffinity probe.

Spletstoser JT, Flaherty PT, Himes RH, Georg GI. Spletstoser JT, et al. Among authors: himes rh. J Med Chem. 2004 Dec 16;47(26):6459-65. doi: 10.1021/jm030581d. J Med Chem. 2004. PMID: 15588080

6

Synthesis and interactions of 7-deoxy-, 10-deacetoxy, and 10-deacetoxy-7-deoxypaclitaxel with NCI/ADR-RES cancer cells and bovine brain microvessel endothelial cells.

Ge H, Vasandani V, Huff JK, Audus KL, Himes RH, Seelig A, Georg GI. Ge H, et al. Among authors: himes rh. Bioorg Med Chem Lett. 2006 Jan 15;16(2):433-6. doi: 10.1016/j.bmcl.2005.09.043. Epub 2005 Nov 3. Bioorg Med Chem Lett. 2006. PMID: 16271474

7

Synthesis, in vitro and in vivo cytotoxicity of 6,7-diaryl-2,3,8,8a-tetrahydroindolizin-5(1H)-ones.

Kimball FS, Tunoori AR, Victory SF, Dutta D, White JM, Himes RH, Georg GI. Kimball FS, et al. Among authors: himes rh. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4703-7. doi: 10.1016/j.bmcl.2007.05.103. Epub 2007 Jun 13. Bioorg Med Chem Lett. 2007. PMID: 17614274 Free PMC article.

8

Enantiospecific synthesis and cytotoxicity of 7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5(1H)-one enantiomers.

Kimball FS, Turunen BJ, Ellis KC, Himes RH, Georg GI. Kimball FS, et al. Among authors: himes rh. Bioorg Med Chem. 2008 Apr 15;16(8):4367-77. doi: 10.1016/j.bmc.2008.02.073. Epub 2008 Mar 4. Bioorg Med Chem. 2008. PMID: 18343127 Free PMC article.

9

Synthesis and evaluation of heteroaromatic 6,7-diaryl-2,3,8,8a-tetrahydroindolizin-5(1H)-ones for cytotoxicity against the HCT-116 colon cancer cell line.

Kimball FS, Himes RH, Georg GI. Kimball FS, et al. Among authors: himes rh. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3248-50. doi: 10.1016/j.bmcl.2008.04.051. Epub 2008 Apr 25. Bioorg Med Chem Lett. 2008. PMID: 18479919 Free PMC article.

10

Synthesis, tubulin assembly, and antiproliferative activity against MCF7 and NCI/ADR-RES cancer cells of 10-O-acetyl-5'-hydroxybutitaxel.

Ge H, Wang J, Kayser MM, Himes RH, Georg GI. Ge H, et al. Among authors: himes rh. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6165-7. doi: 10.1016/j.bmcl.2008.10.010. Epub 2008 Oct 7. Bioorg Med Chem Lett. 2008. PMID: 18977659 Free PMC article.

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