Hilvert D - Search Results

1

Closely related antibody receptors exploit fundamentally different strategies for steroid recognition.

Verdino P, Aldag C, Hilvert D, Wilson IA. Verdino P, et al. Among authors: hilvert d. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11725-30. doi: 10.1073/pnas.0801783105. Epub 2008 Aug 8. Proc Natl Acad Sci U S A. 2008. PMID: 18689687 Free PMC article.

2

Structural origins of efficient proton abstraction from carbon by a catalytic antibody.

Debler EW, Ito S, Seebeck FP, Heine A, Hilvert D, Wilson IA. Debler EW, et al. Among authors: hilvert d. Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):4984-9. doi: 10.1073/pnas.0409207102. Epub 2005 Mar 23. Proc Natl Acad Sci U S A. 2005. PMID: 15788533 Free PMC article.

3

An aspartate and a water molecule mediate efficient acid-base catalysis in a tailored antibody pocket.

Debler EW, Müller R, Hilvert D, Wilson IA. Debler EW, et al. Among authors: hilvert d. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18539-44. doi: 10.1073/pnas.0902700106. Epub 2009 Oct 21. Proc Natl Acad Sci U S A. 2009. PMID: 19846764 Free PMC article.

4

Probing ligand recognition in the decarboxylase antibody 21D8: implications for the catalytic mechanism.

Hotta K, Wilson IA, Hilvert D. Hotta K, et al. Among authors: hilvert d. Biochemistry. 2002 Jan 22;41(3):772-9. doi: 10.1021/bi0158167. Biochemistry. 2002. PMID: 11790098

5

Conformational isomerism can limit antibody catalysis.

Debler EW, Müller R, Hilvert D, Wilson IA. Debler EW, et al. Among authors: hilvert d. J Biol Chem. 2008 Jun 13;283(24):16554-60. doi: 10.1074/jbc.M710256200. Epub 2008 Apr 16. J Biol Chem. 2008. PMID: 18417480 Free PMC article.

6

Probing the role of the proximal heme ligand in cytochrome P450cam by recombinant incorporation of selenocysteine.

Aldag C, Gromov IA, García-Rubio I, von Koenig K, Schlichting I, Jaun B, Hilvert D. Aldag C, et al. Among authors: hilvert d. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5481-6. doi: 10.1073/pnas.0810503106. Epub 2009 Mar 17. Proc Natl Acad Sci U S A. 2009. PMID: 19293375 Free PMC article.

7

Switching antibody specificity through minimal mutation.

Piatesi A, Aldag C, Hilvert D. Piatesi A, et al. Among authors: hilvert d. J Mol Biol. 2008 Apr 4;377(4):993-1001. doi: 10.1016/j.jmb.2008.01.069. Epub 2008 Feb 2. J Mol Biol. 2008. PMID: 18295792

8

Routes to catalysis: structure of a catalytic antibody and comparison with its natural counterpart.

Haynes MR, Stura EA, Hilvert D, Wilson IA. Haynes MR, et al. Among authors: hilvert d. Science. 1994 Feb 4;263(5147):646-52. doi: 10.1126/science.8303271. Science. 1994. PMID: 8303271

9

Evolution of shape complementarity and catalytic efficiency from a primordial antibody template.

Xu J, Deng Q, Chen J, Houk KN, Bartek J, Hilvert D, Wilson IA. Xu J, et al. Among authors: hilvert d. Science. 1999 Dec 17;286(5448):2345-8. doi: 10.1126/science.286.5448.2345. Science. 1999. PMID: 10600746

10

Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structures of abzyme 21D8.

Hotta K, Lange H, Tantillo DJ, Houk KN, Hilvert D, Wilson IA. Hotta K, et al. Among authors: hilvert d. J Mol Biol. 2000 Oct 6;302(5):1213-25. doi: 10.1006/jmbi.2000.4503. J Mol Biol. 2000. PMID: 11183784

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