Caffrey CR - Search Results

1

A parasite cysteine protease is key to host protein degradation and iron acquisition.

O'Brien TC, Mackey ZB, Fetter RD, Choe Y, O'Donoghue AJ, Zhou M, Craik CS, Caffrey CR, McKerrow JH. O'Brien TC, et al. Among authors: caffrey cr. J Biol Chem. 2008 Oct 24;283(43):28934-43. doi: 10.1074/jbc.M805824200. Epub 2008 Aug 13. J Biol Chem. 2008. PMID: 18701454 Free PMC article.

2

Cysteine protease inhibitors as chemotherapy for parasitic infections.

McKerrow JH, Engel JC, Caffrey CR. McKerrow JH, et al. Among authors: caffrey cr. Bioorg Med Chem. 1999 Apr;7(4):639-44. doi: 10.1016/s0968-0896(99)00008-5. Bioorg Med Chem. 1999. PMID: 10353643 Review.

3

Identification of a cDNA encoding an active asparaginyl endopeptidase of Schistosoma mansoni and its expression in Pichia pastoris.

Caffrey CR, Mathieu MA, Gaffney AM, Salter JP, Sajid M, Lucas KD, Franklin C, Bogyo M, McKerrow JH. Caffrey CR, et al. FEBS Lett. 2000 Jan 28;466(2-3):244-8. doi: 10.1016/s0014-5793(99)01798-6. FEBS Lett. 2000. PMID: 10682836 Free article.

4

Aryl ureas represent a new class of anti-trypanosomal agents.

Du X, Hansell E, Engel JC, Caffrey CR, Cohen FE, McKerrow JH. Du X, et al. Among authors: caffrey cr. Chem Biol. 2000 Sep;7(9):733-42. doi: 10.1016/s1074-5521(00)00018-1. Chem Biol. 2000. PMID: 10980453

5

Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense.

Caffrey CR, Hansell E, Lucas KD, Brinen LS, Alvarez Hernandez A, Cheng J, Gwaltney SL 2nd, Roush WR, Stierhof YD, Bogyo M, Steverding D, McKerrow JH. Caffrey CR, et al. Mol Biochem Parasitol. 2001 Nov;118(1):61-73. doi: 10.1016/s0166-6851(01)00368-1. Mol Biochem Parasitol. 2001. PMID: 11704274

6

Screening of acyl hydrazide proteinase inhibitors for antiparasitic activity against Trypanosoma brucei.

Caffrey CR, Schanz M, Nkemngu NJ, Brush M, Hansell E, Cohen FE, Flaherty TM, McKerrow JH, Steverding D. Caffrey CR, et al. Int J Antimicrob Agents. 2002 Mar;19(3):227-31. doi: 10.1016/s0924-8579(01)00488-5. Int J Antimicrob Agents. 2002. PMID: 11932146

7

SmCB2, a novel tegumental cathepsin B from adult Schistosoma mansoni.

Caffrey CR, Salter JP, Lucas KD, Khiem D, Hsieh I, Lim KC, Ruppel A, McKerrow JH, Sajid M. Caffrey CR, et al. Mol Biochem Parasitol. 2002 Apr 30;121(1):49-61. doi: 10.1016/s0166-6851(02)00022-1. Mol Biochem Parasitol. 2002. PMID: 11985862

8

Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries.

Mathieu MA, Bogyo M, Caffrey CR, Choe Y, Lee J, Chapman H, Sajid M, Craik CS, McKerrow JH. Mathieu MA, et al. Among authors: caffrey cr. Mol Biochem Parasitol. 2002 Apr 30;121(1):99-105. doi: 10.1016/s0166-6851(02)00026-9. Mol Biochem Parasitol. 2002. PMID: 11985866

9

Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain.

Du X, Guo C, Hansell E, Doyle PS, Caffrey CR, Holler TP, McKerrow JH, Cohen FE. Du X, et al. Among authors: caffrey cr. J Med Chem. 2002 Jun 20;45(13):2695-707. doi: 10.1021/jm010459j. J Med Chem. 2002. PMID: 12061873

10

Improved trypanocidal activities of cathepsin L inhibitors.

Nkemgu NJ, Grande R, Hansell E, McKerrow JH, Caffrey CR, Steverding D. Nkemgu NJ, et al. Among authors: caffrey cr. Int J Antimicrob Agents. 2003 Aug;22(2):155-9. doi: 10.1016/s0924-8579(03)00096-7. Int J Antimicrob Agents. 2003. PMID: 12927956

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