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Page 1
Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis.
Faust HJ, Cheng TY, Korsunsky I, Watts GFM, Gal-Oz ST, Trim WV, Kongthong S, Jonsson AH, Simmons DP, Zhang F, Padera R, Chubinskaya S; Accelerating Medicines Partnership: RA/SLE Network; Wei K, Raychaudhuri S, Lynch L, Moody DB, Brenner MB. Faust HJ, et al. Nat Commun. 2024 Nov 14;15(1):9859. doi: 10.1038/s41467-024-52586-x. Nat Commun. 2024. PMID: 39543086 Free PMC article.
Automated multi-scale computational pathotyping (AMSCP) of inflamed synovial tissue.
Bell RD, Brendel M, Konnaris MA, Xiang J, Otero M, Fontana MA, Bai Z; Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium; Krenitsky DM, Meednu N, Rangel-Moreno J, Scheel-Toellner D, Carr H, Nayar S, McMurray J, DiCarlo E, Anolik JH, Donlin LT, Orange DE, Kenney HM, Schwarz EM, Filer A, Ivashkiv LB, Wang F. Bell RD, et al. Nat Commun. 2024 Aug 29;15(1):7503. doi: 10.1038/s41467-024-51012-6. Nat Commun. 2024. PMID: 39209814 Free PMC article.
Publisher Correction: Interferon subverts an AHR-JUN axis to promote CXCL13+ T cells in lupus.
Law C, Wacleche VS, Cao Y, Pillai A, Sowerby J, Hancock B, Horisberger A, Bracero S, Skidanova V, Li Z, Adejoorin I, Dillon E, Benque IJ, Nunez DP, Simmons DP, Keegan J, Chen L, Baker T, Brohawn PZ, Al-Mossawi H, Hao LY, Jones B, Rao N, Qu Y, Alves SE; Accelerating Medicines Partnership: RA/SLE Network; Jonsson AH, Shaw KS, Vleugels RA, Massarotti E, Costenbader KH, Brenner MB, Lederer JA, Hultquist JF, Choi J, Rao DA. Law C, et al. Nature. 2024 Aug;632(8025):E6. doi: 10.1038/s41586-024-07845-8. Nature. 2024. PMID: 39060417 No abstract available.
Interferon subverts an AHR-JUN axis to promote CXCL13+ T cells in lupus.
Law C, Wacleche VS, Cao Y, Pillai A, Sowerby J, Hancock B, Horisberger A, Bracero S, Skidanova V, Li Z, Adejoorin I, Dillon E, Benque IJ, Nunez DP, Simmons DP, Keegan J, Chen L, Baker T, Brohawn PZ, Al-Mossawi H, Hao LY, Jones B, Rao N, Qu Y, Alves SE; Accelerating Medicines Partnership: RA/SLE Network; Jonsson AH, Shaw KS, Vleugels RA, Massarotti E, Costenbader KH, Brenner MB, Lederer JA, Hultquist JF, Choi J, Rao DA. Law C, et al. Nature. 2024 Jul;631(8022):857-866. doi: 10.1038/s41586-024-07627-2. Epub 2024 Jul 10. Nature. 2024. PMID: 38987586
Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium.
Dunlap G, Wagner A, Meednu N, Wang R, Zhang F, Ekabe JC, Jonsson AH, Wei K, Sakaue S, Nathan A; Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network; Bykerk VP, Donlin LT, Goodman SM, Firestein GS, Boyle DL, Holers VM, Moreland LW, Tabechian D, Pitzalis C, Filer A, Raychaudhuri S, Brenner MB, Thakar J, McDavid A, Rao DA, Anolik JH. Dunlap G, et al. Nat Commun. 2024 Jun 11;15(1):4991. doi: 10.1038/s41467-024-49186-0. Nat Commun. 2024. PMID: 38862501 Free PMC article.
The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritis.
Weinand K, Sakaue S, Nathan A, Jonsson AH, Zhang F, Watts GFM, Al Suqri M, Zhu Z; Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network; Rao DA, Anolik JH, Brenner MB, Donlin LT, Wei K, Raychaudhuri S. Weinand K, et al. Nat Commun. 2024 May 31;15(1):4650. doi: 10.1038/s41467-024-48620-7. Nat Commun. 2024. PMID: 38821936 Free PMC article.
Synovial fibroblast gene expression is associated with sensory nerve growth and pain in rheumatoid arthritis.
Bai Z, Bartelo N, Aslam M, Murphy EA, Hale CR, Blachere NE, Parveen S, Spolaore E, DiCarlo E, Gravallese EM, Smith MH; Accelerating Medicines Partnership RA/SLE Network; Frank MO, Jiang CS, Zhang H, Pyrgaki C, Lewis MJ, Sikandar S, Pitzalis C, Lesnak JB, Mazhar K, Price TJ, Malfait AM, Miller RE, Zhang F, Goodman S, Darnell RB, Wang F, Orange DE. Bai Z, et al. Sci Transl Med. 2024 Apr 10;16(742):eadk3506. doi: 10.1126/scitranslmed.adk3506. Epub 2024 Apr 10. Sci Transl Med. 2024. PMID: 38598614
Tissue-specific enhancer-gene maps from multimodal single-cell data identify causal disease alleles.
Sakaue S, Weinand K, Isaac S, Dey KK, Jagadeesh K, Kanai M, Watts GFM, Zhu Z; Accelerating Medicines Partnership® RA/SLE Program and Network; Brenner MB, McDavid A, Donlin LT, Wei K, Price AL, Raychaudhuri S. Sakaue S, et al. Nat Genet. 2024 Apr;56(4):615-626. doi: 10.1038/s41588-024-01682-1. Epub 2024 Apr 9. Nat Genet. 2024. PMID: 38594305 Free PMC article.
Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution.
Kang JB, Shen AZ, Gurajala S, Nathan A, Rumker L, Aguiar VRC, Valencia C, Lagattuta KA, Zhang F, Jonsson AH, Yazar S, Alquicira-Hernandez J, Khalili H, Ananthakrishnan AN, Jagadeesh K, Dey K; Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network; Daly MJ, Xavier RJ, Donlin LT, Anolik JH, Powell JE, Rao DA, Brenner MB, Gutierrez-Arcelus M, Luo Y, Sakaue S, Raychaudhuri S. Kang JB, et al. Nat Genet. 2023 Dec;55(12):2255-2268. doi: 10.1038/s41588-023-01586-6. Epub 2023 Nov 30. Nat Genet. 2023. PMID: 38036787 Free PMC article.
Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes.
Zhang F, Jonsson AH, Nathan A, Millard N, Curtis M, Xiao Q, Gutierrez-Arcelus M, Apruzzese W, Watts GFM, Weisenfeld D, Nayar S, Rangel-Moreno J, Meednu N, Marks KE, Mantel I, Kang JB, Rumker L, Mears J, Slowikowski K, Weinand K, Orange DE, Geraldino-Pardilla L, Deane KD, Tabechian D, Ceponis A, Firestein GS, Maybury M, Sahbudin I, Ben-Artzi A, Mandelin AM 2nd, Nerviani A, Lewis MJ, Rivellese F, Pitzalis C, Hughes LB, Horowitz D, DiCarlo E, Gravallese EM, Boyce BF; Accelerating Medicines Partnership: RA/SLE Network; Moreland LW, Goodman SM, Perlman H, Holers VM, Liao KP, Filer A, Bykerk VP, Wei K, Rao DA, Donlin LT, Anolik JH, Brenner MB, Raychaudhuri S. Zhang F, et al. Among authors: mandelin am 2nd. Nature. 2023 Nov;623(7987):616-624. doi: 10.1038/s41586-023-06708-y. Epub 2023 Nov 8. Nature. 2023. PMID: 37938773 Free PMC article.
32 results