Macias WL - Search Results

1

Influence of enrollment sequence effect on observed outcomes in the ADDRESS and PROWESS studies of drotrecogin alfa (activated) in patients with severe sepsis.

Laterre PF, Macias WL, Janes J, Williams MD, Nelson DR, Girbes AR, Dhainaut JF, Abraham E. Laterre PF, et al. Among authors: macias wl. Crit Care. 2008;12(5):R117. doi: 10.1186/cc7011. Epub 2008 Sep 11. Crit Care. 2008. PMID: 18786266 Free PMC article.

2

Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: further evidence for survival and safety and implications for early treatment.

Vincent JL, Bernard GR, Beale R, Doig C, Putensen C, Dhainaut JF, Artigas A, Fumagalli R, Macias W, Wright T, Wong K, Sundin DP, Turlo MA, Janes J. Vincent JL, et al. Crit Care Med. 2005 Oct;33(10):2266-77. doi: 10.1097/01.ccm.0000181729.46010.83. Crit Care Med. 2005. PMID: 16215381 Clinical Trial.

3

International integrated database for the evaluation of severe sepsis and drotrecogin alfa (activated) therapy: 28-day survival and safety.

Laterre PF, Nelson DR, Macias W, Abraham E, Sashegyi A, Williams MD, Levy M, Levi M, Utterback B, Vincent JL. Laterre PF, et al. J Crit Care. 2007 Jun;22(2):142-52. doi: 10.1016/j.jcrc.2006.09.007. Epub 2007 Jan 31. J Crit Care. 2007. PMID: 17548026

4

Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis.

Ely EW, Laterre PF, Angus DC, Helterbrand JD, Levy H, Dhainaut JF, Vincent JL, Macias WL, Bernard GR; PROWESS Investigators. Ely EW, et al. Among authors: macias wl. Crit Care Med. 2003 Jan;31(1):12-9. doi: 10.1097/00003246-200301000-00002. Crit Care Med. 2003. PMID: 12544987 Clinical Trial.

5

Safety assessment of drotrecogin alfa (activated) in the treatment of adult patients with severe sepsis.

Bernard GR, Macias WL, Joyce DE, Williams MD, Bailey J, Vincent JL. Bernard GR, et al. Among authors: macias wl. Crit Care. 2003 Apr;7(2):155-63. doi: 10.1186/cc2167. Epub 2003 Feb 28. Crit Care. 2003. PMID: 12720562 Free PMC article. Review.

6

Sources of variability on the estimate of treatment effect in the PROWESS trial: implications for the design and conduct of future studies in severe sepsis.

Macias WL, Vallet B, Bernard GR, Vincent JL, Laterre PF, Nelson DR, Derchak PA, Dhainaut JF. Macias WL, et al. Crit Care Med. 2004 Dec;32(12):2385-91. doi: 10.1097/01.ccm.0000147440.71142.ac. Crit Care Med. 2004. PMID: 15599140 Clinical Trial.

7

Lack of evidence for qualitative treatment by disease severity interactions in clinical studies of severe sepsis.

Macias WL, Nelson DR, Williams M, Garg R, Janes J, Sashegyi A. Macias WL, et al. Crit Care. 2005;9(6):R607-22. doi: 10.1186/cc3795. Epub 2005 Sep 22. Crit Care. 2005. PMID: 16280057 Free PMC article. Review.

8

International INtegrated Database for the Evaluation of severe sePsis and drotrecogin alfa (activated) THerapy: component trials and statistical methods for INDEPTH.

Sashegyi A, Trzaskoma BL, Nelson DR, Williams MD, Macias W. Sashegyi A, et al. Curr Med Res Opin. 2006 May;22(5):1001-12. doi: 10.1185/030079906X104713. Curr Med Res Opin. 2006. PMID: 16709322

9

Pharmacokinetic-pharmacodynamic analysis of drotrecogin alfa (activated) in patients with severe sepsis.

Macias WL, Dhainaut JF, Yan SC, Helterbrand JD, Seger M, Johnson G 3rd, Small DS. Macias WL, et al. Clin Pharmacol Ther. 2002 Oct;72(4):391-402. doi: 10.1067/mcp.2002.128148. Clin Pharmacol Ther. 2002. PMID: 12386641 Clinical Trial.

10

Dynamic evolution of coagulopathy in the first day of severe sepsis: relationship with mortality and organ failure.

Dhainaut JF, Shorr AF, Macias WL, Kollef MJ, Levi M, Reinhart K, Nelson DR. Dhainaut JF, et al. Among authors: macias wl. Crit Care Med. 2005 Feb;33(2):341-8. doi: 10.1097/01.ccm.0000153520.31562.48. Crit Care Med. 2005. PMID: 15699837

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