Mittapalli RK - Search Results

1

bis-Pyridinium cyclophanes: novel ligands with high affinity for the blood-brain barrier choline transporter.

Zhang Z, Lockman PR, Mittapalli RK, Allen DD, Dwoskin LP, Crooks PA. Zhang Z, et al. Among authors: mittapalli rk. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5622-5. doi: 10.1016/j.bmcl.2008.08.099. Epub 2008 Aug 30. Bioorg Med Chem Lett. 2008. PMID: 18793853 Free PMC article.

2

Predictive screening model for potential vector-mediated transport of cationic substrates at the blood-brain barrier choline transporter.

Geldenhuys WJ, Manda VK, Mittapalli RK, Van der Schyf CJ, Crooks PA, Dwoskin LP, Allen DD, Lockman PR. Geldenhuys WJ, et al. Among authors: mittapalli rk. Bioorg Med Chem Lett. 2010 Feb 1;20(3):870-7. doi: 10.1016/j.bmcl.2009.12.079. Epub 2009 Dec 28. Bioorg Med Chem Lett. 2010. PMID: 20053562 Free PMC article.

3

Exploiting nutrient transporters at the blood-brain barrier to improve brain distribution of small molecules.

Mittapalli RK, Manda VK, Adkins CE, Geldenhuys WJ, Lockman PR. Mittapalli RK, et al. Ther Deliv. 2010 Dec;1(6):775-84. doi: 10.4155/tde.10.76. Ther Deliv. 2010. PMID: 22834013 Review.

4

Carrier-mediated transport of the quaternary ammonium neuronal nicotinic receptor antagonist n,n'-dodecylbispicolinium dibromide at the blood-brain barrier.

Lockman PR, Manda VK, Geldenhuys WJ, Mittapalli RK, Thomas F, Albayati ZF, Crooks PA, Dwoskin LP, Allen DD. Lockman PR, et al. Among authors: mittapalli rk. J Pharmacol Exp Ther. 2008 Jan;324(1):244-50. doi: 10.1124/jpet.107.130906. Epub 2007 Oct 5. J Pharmacol Exp Ther. 2008. PMID: 17921191

5

Uptake of ANG1005, a novel paclitaxel derivative, through the blood-brain barrier into brain and experimental brain metastases of breast cancer.

Thomas FC, Taskar K, Rudraraju V, Goda S, Thorsheim HR, Gaasch JA, Mittapalli RK, Palmieri D, Steeg PS, Lockman PR, Smith QR. Thomas FC, et al. Among authors: mittapalli rk. Pharm Res. 2009 Nov;26(11):2486-94. doi: 10.1007/s11095-009-9964-5. Epub 2009 Sep 23. Pharm Res. 2009. PMID: 19774344 Free PMC article.

6

Chronic exposure to nicotine and saquinavir decreases endothelial Notch-4 expression and disrupts blood-brain barrier integrity.

Manda VK, Mittapalli RK, Geldenhuys WJ, Lockman PR. Manda VK, et al. Among authors: mittapalli rk. J Neurochem. 2010 Oct;115(2):515-25. doi: 10.1111/j.1471-4159.2010.06948.x. Epub 2010 Aug 30. J Neurochem. 2010. PMID: 20722969 Free article.

7

Nicotine and cotinine increases the brain penetration of saquinavir in rat.

Manda VK, Mittapalli RK, Bohn KA, Adkins CE, Lockman PR. Manda VK, et al. Among authors: mittapalli rk. J Neurochem. 2010 Dec;115(6):1495-507. doi: 10.1111/j.1471-4159.2010.07054.x. Epub 2010 Nov 11. J Neurochem. 2010. PMID: 20950334 Free article.

8

Quantitative fluorescence microscopy provides high resolution imaging of passive diffusion and P-gp mediated efflux at the in vivo blood-brain barrier.

Mittapalli RK, Manda VK, Bohn KA, Adkins CE, Lockman PR. Mittapalli RK, et al. J Neurosci Methods. 2013 Sep 30;219(1):188-95. doi: 10.1016/j.jneumeth.2013.07.001. Epub 2013 Aug 2. J Neurosci Methods. 2013. PMID: 23916719 Free PMC article.

9

Heterogeneous blood-tumor barrier permeability determines drug efficacy in experimental brain metastases of breast cancer.

Lockman PR, Mittapalli RK, Taskar KS, Rudraraju V, Gril B, Bohn KA, Adkins CE, Roberts A, Thorsheim HR, Gaasch JA, Huang S, Palmieri D, Steeg PS, Smith QR. Lockman PR, et al. Among authors: mittapalli rk. Clin Cancer Res. 2010 Dec 1;16(23):5664-78. doi: 10.1158/1078-0432.CCR-10-1564. Epub 2010 Sep 9. Clin Cancer Res. 2010. PMID: 20829328 Free PMC article.

10

A novel preclinical method to quantitatively evaluate early-stage metastatic events at the murine blood-brain barrier.

Adkins CE, Nounou MI, Mittapalli RK, Terrell-Hall TB, Mohammad AS, Jagannathan R, Lockman PR. Adkins CE, et al. Among authors: mittapalli rk. Cancer Prev Res (Phila). 2015 Jan;8(1):68-76. doi: 10.1158/1940-6207.CAPR-14-0225. Epub 2014 Oct 27. Cancer Prev Res (Phila). 2015. PMID: 25348853 Free PMC article.

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