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Both IL-12 and IL-18 contribute to small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii, but IL-12 is dominant over IL-18 in parasite control.
Vossenkämper A, Struck D, Alvarado-Esquivel C, Went T, Takeda K, Akira S, Pfeffer K, Alber G, Lochner M, Förster I, Liesenfeld O. Vossenkämper A, et al. Among authors: liesenfeld o. Eur J Immunol. 2004 Nov;34(11):3197-207. doi: 10.1002/eji.200424993. Eur J Immunol. 2004. PMID: 15368276 Free article.
Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17.
Muñoz M, Heimesaat MM, Danker K, Struck D, Lohmann U, Plickert R, Bereswill S, Fischer A, Dunay IR, Wolk K, Loddenkemper C, Krell HW, Libert C, Lund LR, Frey O, Hölscher C, Iwakura Y, Ghilardi N, Ouyang W, Kamradt T, Sabat R, Liesenfeld O. Muñoz M, et al. Among authors: liesenfeld o. J Exp Med. 2009 Dec 21;206(13):3047-59. doi: 10.1084/jem.20090900. Epub 2009 Dec 7. J Exp Med. 2009. PMID: 19995958 Free PMC article.
Treatment with interleukin-18 binding protein ameliorates Toxoplasma gondii-induced small intestinal pathology that is induced by bone marrow cell-derived interleukin-18.
Struck D, Frank I, Enders S, Steinhoff U, Schmidt C, Stallmach A, Liesenfeld O, Heimesaat MM. Struck D, et al. Among authors: liesenfeld o. Eur J Microbiol Immunol (Bp). 2012 Sep;2(3):249-57. doi: 10.1556/EuJMI.2.2012.3.11. Epub 2012 Sep 10. Eur J Microbiol Immunol (Bp). 2012. PMID: 24688772 Free PMC article.
207 results