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Ikaros represses the transcriptional response to Notch signaling in T-cell development.
Mol Cell Biol. 2008 Dec;28(24):7465-75. doi: 10.1128/MCB.00715-08. Epub 2008 Oct 13.
Mol Cell Biol. 2008.
PMID: 18852286
Free PMC article.
Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL.
Jeannet R, Mastio J, Macias-Garcia A, Oravecz A, Ashworth T, Geimer Le Lay AS, Jost B, Le Gras S, Ghysdael J, Gridley T, Honjo T, Radtke F, Aster JC, Chan S, Kastner P.
Jeannet R, et al. Among authors: geimer le lay as.
Blood. 2010 Dec 16;116(25):5443-54. doi: 10.1182/blood-2010-05-286658. Epub 2010 Sep 9.
Blood. 2010.
PMID: 20829372
Free PMC article.
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The tumor suppressor Ikaros shapes the repertoire of notch target genes in T cells.
Geimer Le Lay AS, Oravecz A, Mastio J, Jung C, Marchal P, Ebel C, Dembélé D, Jost B, Le Gras S, Thibault C, Borggrefe T, Kastner P, Chan S.
Geimer Le Lay AS, et al.
Sci Signal. 2014 Mar 18;7(317):ra28. doi: 10.1126/scisignal.2004545.
Sci Signal. 2014.
PMID: 24643801
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