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Hypothesizing that brain reward circuitry genes are genetic antecedents of pain sensitivity and critical diagnostic and pharmacogenomic treatment targets for chronic pain conditions.
Chen AL, Chen TJ, Waite RL, Reinking J, Tung HL, Rhoades P, Downs BW, Braverman E, Braverman D, Kerner M, Blum SH, DiNubile N, Smith D, Oscar-Berman M, Prihoda TJ, Floyd JB, O'Brien D, Liu HH, Blum K. Chen AL, et al. Among authors: smith d. Med Hypotheses. 2009 Jan;72(1):14-22. doi: 10.1016/j.mehy.2008.07.059. Epub 2008 Oct 31. Med Hypotheses. 2009. PMID: 18951726 Free PMC article. Review.
Genetic addiction risk score (GARS) ™, a predictor of vulnerability to opioid dependence.
Blum K, Chen ALC, Thanos PK, Febo M, Demetrovics Z, Dushaj K, Kovoor A, Baron D, Smith DE, Roy AK III, Fried L, Chen TJH, Chapman E Sr, Modestino EJ, Steinberg B, Badgaiyan RD. Blum K, et al. Among authors: smith de. Front Biosci (Elite Ed). 2018 Jan 1;10(1):175-196. doi: 10.2741/e816. Front Biosci (Elite Ed). 2018. PMID: 28930612 Free article. Review.
Proposing a "Brain Health Checkup (BHC)" as a Global Potential "Standard of Care" to Overcome Reward Dysregulation in Primary Care Medicine: Coupling Genetic Risk Testing and Induction of "Dopamine Homeostasis".
Braverman ER, Dennen CA, Gold MS, Bowirrat A, Gupta A, Baron D, Roy AK, Smith DE, Cadet JL, Blum K. Braverman ER, et al. Among authors: smith de. Int J Environ Res Public Health. 2022 Apr 30;19(9):5480. doi: 10.3390/ijerph19095480. Int J Environ Res Public Health. 2022. PMID: 35564876 Free PMC article.
High Genetic Addiction Risk Score (GARS) in Chronically Prescribed Severe Chronic Opioid Probands Attending Multi-pain Clinics: an Open Clinical Pilot Trial.
Moran M, Blum K, Ponce JV, Lott L, Gondré-Lewis MC, Badgaiyan S, Brewer R, Downs BW, Fynman P, Weingarten A, Cadet JL, Smith DE, Baron D, Thanos PK, Modestino EJ, Badgaiyan RD, Elman I, Gold MS. Moran M, et al. Among authors: smith de. Mol Neurobiol. 2021 Jul;58(7):3335-3346. doi: 10.1007/s12035-021-02312-1. Epub 2021 Mar 8. Mol Neurobiol. 2021. PMID: 33683627 Free PMC article. Clinical Trial.
Systematic evaluation of "compliance" to prescribed treatment medications and "abstinence" from psychoactive drug abuse in chemical dependence programs: data from the comprehensive analysis of reported drugs.
Blum K, Han D, Femino J, Smith DE, Saunders S, Simpatico T, Schoenthaler SJ, Oscar-Berman M, Gold MS. Blum K, et al. Among authors: smith de. PLoS One. 2014 Sep 23;9(9):e104275. doi: 10.1371/journal.pone.0104275. eCollection 2014. PLoS One. 2014. PMID: 25247439 Free PMC article.
Neurobiology and Spirituality in Addiction Recovery.
Roy AK, Bowirrat A, Smith DE, Braverman ER, Jalali R, Badgaiyan RD, Baron D, Llanos-Gomez L, Barh D, Blum K. Roy AK, et al. Among authors: smith de. Acta Sci Neurol. 2021 Aug 28;4(9):64-71. Acta Sci Neurol. 2021. PMID: 35098052 Free PMC article.
A Systematic, Intensive Statistical Investigation of Data from the Comprehensive Analysis of Reported Drugs (CARD) for Compliance and Illicit Opioid Abstinence in Substance Addiction Treatment with Buprenorphine/naloxone.
Blum K, Han D, Modestino EJ, Saunders S, Roy AK 3rd, Jacobs W, Inaba DS, Baron D, Oscar-Berman M, Hauser M, Badgaiyan RD, Smith DE, Femino J, Gold MS. Blum K, et al. Among authors: smith de. Subst Use Misuse. 2018 Jan 28;53(2):220-229. doi: 10.1080/10826084.2017.1400064. Epub 2017 Dec 19. Subst Use Misuse. 2018. PMID: 29257919 Free article.
Neurogenetic and epigenetic correlates of adolescent predisposition to and risk for addictive behaviors as a function of prefrontal cortex dysregulation.
Blum K, Febo M, Smith DE, Roy AK 3rd, Demetrovics Z, Cronjé FJ, Femino J, Agan G, Fratantonio JL, Pandey SC, Badgaiyan RD, Gold MS. Blum K, et al. Among authors: smith de. J Child Adolesc Psychopharmacol. 2015 May;25(4):286-92. doi: 10.1089/cap.2014.0146. Epub 2015 Apr 28. J Child Adolesc Psychopharmacol. 2015. PMID: 25919973 Free PMC article. Review.
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