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79 results

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Page 1
The synthesis of substituted bipiperidine amide compounds as CCR3 antagonists.
Ting PC, Lee JF, Wu J, Umland SP, Aslanian R, Cao J, Dong Y, Garlisi CG, Gilbert EJ, Huang Y, Jakway J, Kelly J, Liu Z, McCombie S, Shah H, Tian F, Wan Y, Shih NY. Ting PC, et al. Among authors: mccombie s. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1375-8. doi: 10.1016/j.bmcl.2005.01.016. Bioorg Med Chem Lett. 2005. PMID: 15713390
Non-aromatic A-ring replacement in the triaryl bis-sulfone CB2 receptor inhibitors.
Gilbert EJ, Zhou G, Wong MK, Tong L, Shankar BB, Huang C, Kelly J, Lavey BJ, McCombie SW, Chen L, Rizvi R, Dong Y, Shu Y, Kozlowski JA, Shih NY, Hipkin RW, Gonsiorek W, Malikzay A, Lunn CA, Favreau L, Lundell DJ. Gilbert EJ, et al. Bioorg Med Chem Lett. 2010 Jan 15;20(2):608-11. doi: 10.1016/j.bmcl.2009.11.084. Epub 2009 Nov 22. Bioorg Med Chem Lett. 2010. PMID: 20005710
Muscarinic agonists and antagonists in the treatment of Alzheimer's disease.
Greenlee W, Clader J, Asberom T, McCombie S, Ford J, Guzik H, Kozlowski J, Li S, Liu C, Lowe D, Vice S, Zhao H, Zhou G, Billard W, Binch H, Crosby R, Duffy R, Lachowicz J, Coffin V, Watkins R, Ruperto V, Strader C, Taylor L, Cox K. Greenlee W, et al. Among authors: mccombie s. Farmaco. 2001 Apr;56(4):247-50. doi: 10.1016/s0014-827x(01)01102-8. Farmaco. 2001. PMID: 11421251 Review.
Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M(2) muscarinic receptor antagonists via benzamide modification.
Boyle CD, Vice SF, Campion J, Chackalamannil S, Lankin CM, McCombie SW, Billard W, Binch H 3rd, Crosby G, Williams MC, Coffin VL, Cox KA, Grotz DE, Duffy RA, Ruperto V, Lachowicz JE. Boyle CD, et al. Among authors: mccombie sw. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3479-82. doi: 10.1016/s0960-894x(02)00742-4. Bioorg Med Chem Lett. 2002. PMID: 12419388
Substituted 2-(R)-methyl piperazines as muscarinic M(2) selective ligands.
Kozlowski JA, Zhou G, Tagat JR, Lin SI, McCombie SW, Ruperto VB, Duffy RA, McQuade RA, Crosby G, Taylor LA, Billard W, Binch H, Lachowicz JE. Kozlowski JA, et al. Bioorg Med Chem Lett. 2002 Mar 11;12(5):791-4. doi: 10.1016/s0960-894x(02)00023-9. Bioorg Med Chem Lett. 2002. PMID: 11859004
Piperazine-based CCR5 antagonists as HIV-1 inhibitors. IV. Discovery of 1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-[2-methoxy-1(R)-4-(trifluoromethyl)phenyl]ethyl-3(S)-methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a potent, highly selective, and orally bioavailable CCR5 antagonist.
Tagat JR, McCombie SW, Nazareno D, Labroli MA, Xiao Y, Steensma RW, Strizki JM, Baroudy BM, Cox K, Lachowicz J, Varty G, Watkins R. Tagat JR, et al. J Med Chem. 2004 May 6;47(10):2405-8. doi: 10.1021/jm0304515. J Med Chem. 2004. PMID: 15115380
79 results