Wang X - Search Results

1

Overcoming mTOR inhibition-induced paradoxical activation of survival signaling pathways enhances mTOR inhibitors' anticancer efficacy.

Wang X, Hawk N, Yue P, Kauh J, Ramalingam SS, Fu H, Khuri FR, Sun SY. Wang X, et al. Cancer Biol Ther. 2008 Dec;7(12):1952-8. doi: 10.4161/cbt.7.12.6944. Epub 2008 Dec 8. Cancer Biol Ther. 2008. PMID: 18981735 Free PMC article.

2

Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.

Sun SY, Rosenberg LM, Wang X, Zhou Z, Yue P, Fu H, Khuri FR. Sun SY, et al. Among authors: wang x. Cancer Res. 2005 Aug 15;65(16):7052-8. doi: 10.1158/0008-5472.CAN-05-0917. Cancer Res. 2005. PMID: 16103051

3

The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway.

Elrod HA, Lin YD, Yue P, Wang X, Lonial S, Khuri FR, Sun SY. Elrod HA, et al. Among authors: wang x. Mol Cancer Ther. 2007 Jul;6(7):2029-38. doi: 10.1158/1535-7163.MCT-07-0004. Epub 2007 Jun 29. Mol Cancer Ther. 2007. PMID: 17604333

4

Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation.

Wang X, Yue P, Chan CB, Ye K, Ueda T, Watanabe-Fukunaga R, Fukunaga R, Fu H, Khuri FR, Sun SY. Wang X, et al. Mol Cell Biol. 2007 Nov;27(21):7405-13. doi: 10.1128/MCB.00760-07. Epub 2007 Aug 27. Mol Cell Biol. 2007. PMID: 17724079 Free PMC article.

5

Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation.

Tang X, Jang SW, Wang X, Liu Z, Bahr SM, Sun SY, Brat D, Gutmann DH, Ye K. Tang X, et al. Among authors: wang x. Nat Cell Biol. 2007 Oct;9(10):1199-207. doi: 10.1038/ncb1641. Epub 2007 Sep 23. Nat Cell Biol. 2007. PMID: 17891137

6

Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/rictor-independent Akt activation.

Wang X, Yue P, Kim YA, Fu H, Khuri FR, Sun SY. Wang X, et al. Cancer Res. 2008 Sep 15;68(18):7409-18. doi: 10.1158/0008-5472.CAN-08-1522. Cancer Res. 2008. PMID: 18794129 Free PMC article.

7

Enhancing mTOR-targeted cancer therapy.

Wang X, Sun SY. Wang X, et al. Expert Opin Ther Targets. 2009 Oct;13(10):1193-203. doi: 10.1517/14728220903225008. Expert Opin Ther Targets. 2009. PMID: 19694499 Free PMC article. Review.

8

Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy.

Fu L, Kim YA, Wang X, Wu X, Yue P, Lonial S, Khuri FR, Sun SY. Fu L, et al. Among authors: wang x. Cancer Res. 2009 Dec 1;69(23):8967-76. doi: 10.1158/0008-5472.CAN-09-2190. Epub 2009 Nov 17. Cancer Res. 2009. PMID: 19920197 Free PMC article.

9

Downregulation of IRS-1 promotes metastasis of head and neck squamous cell carcinoma.

Luo X, Fan S, Huang W, Zhai S, Ma Z, Li P, Sun SY, Wang X. Luo X, et al. Among authors: wang x. Oncol Rep. 2012 Aug;28(2):659-67. doi: 10.3892/or.2012.1846. Epub 2012 Jun 1. Oncol Rep. 2012. PMID: 22664743

10

Perifosine enhances mTORC1-targeted cancer therapy by activation of GSK3β in NSCLC cells.

Ma Z, Zhu L, Luo X, Zhai S, Li P, Wang X. Ma Z, et al. Among authors: wang x. Cancer Biol Ther. 2012 Sep;13(11):1009-17. doi: 10.4161/cbt.20989. Epub 2012 Jul 24. Cancer Biol Ther. 2012. PMID: 22825337 Free PMC article.

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