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Polythiophenes inhibit prion propagation by stabilizing prion protein (PrP) aggregates.
Margalith I, Suter C, Ballmer B, Schwarz P, Tiberi C, Sonati T, Falsig J, Nyström S, Hammarström P, Aslund A, Nilsson KP, Yam A, Whitters E, Hornemann S, Aguzzi A. Margalith I, et al. J Biol Chem. 2012 Jun 1;287(23):18872-87. doi: 10.1074/jbc.M112.355958. Epub 2012 Apr 6. J Biol Chem. 2012. PMID: 22493452 Free PMC article.
Production of site-specific antibody-drug conjugates using optimized non-natural amino acids in a cell-free expression system.
Zimmerman ES, Heibeck TH, Gill A, Li X, Murray CJ, Madlansacay MR, Tran C, Uter NT, Yin G, Rivers PJ, Yam AY, Wang WD, Steiner AR, Bajad SU, Penta K, Yang W, Hallam TJ, Thanos CD, Sato AK. Zimmerman ES, et al. Among authors: yam ay. Bioconjug Chem. 2014 Feb 19;25(2):351-61. doi: 10.1021/bc400490z. Epub 2014 Jan 29. Bioconjug Chem. 2014. PMID: 24437342
RF1 attenuation enables efficient non-natural amino acid incorporation for production of homogeneous antibody drug conjugates.
Yin G, Stephenson HT, Yang J, Li X, Armstrong SM, Heibeck TH, Tran C, Masikat MR, Zhou S, Stafford RL, Yam AY, Lee J, Steiner AR, Gill A, Penta K, Pollitt S, Baliga R, Murray CJ, Thanos CD, McEvoy LM, Sato AK, Hallam TJ. Yin G, et al. Among authors: yam ay. Sci Rep. 2017 Jun 8;7(1):3026. doi: 10.1038/s41598-017-03192-z. Sci Rep. 2017. PMID: 28596531 Free PMC article.
Egg-Derived Anti-SARS-CoV-2 Immunoglobulin Y (IgY) With Broad Variant Activity as Intranasal Prophylaxis Against COVID-19.
Frumkin LR, Lucas M, Scribner CL, Ortega-Heinly N, Rogers J, Yin G, Hallam TJ, Yam A, Bedard K, Begley R, Cohen CA, Badger CV, Abbasi SA, Dye JM, McMillan B, Wallach M, Bricker TL, Joshi A, Boon ACM, Pokhrel S, Kraemer BR, Lee L, Kargotich S, Agochiya M, John TS, Mochly-Rosen D. Frumkin LR, et al. Front Immunol. 2022 Jun 1;13:899617. doi: 10.3389/fimmu.2022.899617. eCollection 2022. Front Immunol. 2022. PMID: 35720389 Free PMC article. Clinical Trial.
Targeting CD74 in multiple myeloma with the novel, site-specific antibody-drug conjugate STRO-001.
Abrahams CL, Li X, Embry M, Yu A, Krimm S, Krueger S, Greenland NY, Wen KW, Jones C, DeAlmeida V, Solis WA, Matheny S, Kline T, Yam AY, Stafford R, Wiita AP, Hallam T, Lupher M, Molina A. Abrahams CL, et al. Among authors: yam ay. Oncotarget. 2018 Dec 28;9(102):37700-37714. doi: 10.18632/oncotarget.26491. eCollection 2018 Dec 28. Oncotarget. 2018. PMID: 30701025 Free PMC article.
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