Sakoff JA - Search Results

1

Norcantharidin analogues: synthesis, anticancer activity and protein phosphatase 1 and 2A inhibition.

Hill TA, Stewart SG, Gordon CP, Ackland SP, Gilbert J, Sauer B, Sakoff JA, McCluskey A. Hill TA, et al. Among authors: sakoff ja. ChemMedChem. 2008 Dec;3(12):1878-92. doi: 10.1002/cmdc.200800192. ChemMedChem. 2008. PMID: 19025735

2

Anhydride modified cantharidin analogues: synthesis, inhibition of protein phosphatases 1 and 2A and anticancer activity.

McCluskey A, Bowyer MC, Collins E, Sim ATR, Sakoff JA, Baldwin ML. McCluskey A, et al. Among authors: sakoff ja. Bioorg Med Chem Lett. 2000 Aug 7;10(15):1687-90. doi: 10.1016/s0960-894x(00)00323-1. Bioorg Med Chem Lett. 2000. PMID: 10937725

3

Thymidylate synthase inhibition induces S-phase arrest, biphasic mitochondrial alterations and caspase-dependent apoptosis in leukaemia cells.

Sakoff JA, Ackland SP. Sakoff JA, et al. Cancer Chemother Pharmacol. 2000;46(6):477-87. doi: 10.1007/s002800000164. Cancer Chemother Pharmacol. 2000. PMID: 11138461

4

Cantharimides: a new class of modified cantharidin analogues inhibiting protein phosphatases 1 and 2A.

McCluskey A, Walkom C, Bowyer MC, Ackland SP, Gardiner E, Sakoff JA. McCluskey A, et al. Among authors: sakoff ja. Bioorg Med Chem Lett. 2001 Nov 19;11(22):2941-6. doi: 10.1016/s0960-894x(01)00594-7. Bioorg Med Chem Lett. 2001. PMID: 11677131

5

The first two cantharidin analogues displaying PP1 selectivity.

McCluskey A, Keane MA, Walkom CC, Bowyer MC, Sim AT, Young DJ, Sakoff JA. McCluskey A, et al. Among authors: sakoff ja. Bioorg Med Chem Lett. 2002 Feb 11;12(3):391-3. doi: 10.1016/s0960-894x(01)00777-6. Bioorg Med Chem Lett. 2002. PMID: 11814804

6

Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies.

McCluskey A, Sim AT, Sakoff JA. McCluskey A, et al. Among authors: sakoff ja. J Med Chem. 2002 Mar 14;45(6):1151-75. doi: 10.1021/jm010066k. J Med Chem. 2002. PMID: 11881984 Review. No abstract available.

7

Anticancer activity and protein phosphatase 1 and 2A inhibition of a new generation of cantharidin analogues.

Sakoff JA, Ackland SP, Baldwin ML, Keane MA, McCluskey A. Sakoff JA, et al. Invest New Drugs. 2002 Feb;20(1):1-11. doi: 10.1023/a:1014460818734. Invest New Drugs. 2002. PMID: 12003183

8

Simple liquid chromatographic method for the determination of uracil and dihydrouracil plasma levels: a potential pretreatment predictor of 5-fluorouracil toxicity.

Garg MB, Sevester JC, Sakoff JA, Ackland SP. Garg MB, et al. Among authors: sakoff ja. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Jul 15;774(2):223-30. doi: 10.1016/s1570-0232(02)00239-8. J Chromatogr B Analyt Technol Biomed Life Sci. 2002. PMID: 12076692

9

Small molecule inhibitors of serine/threonine protein phosphatases.

McCluskey A, Sakoff JA. McCluskey A, et al. Among authors: sakoff ja. Mini Rev Med Chem. 2001 May;1(1):43-55. doi: 10.2174/1389557013407205. Mini Rev Med Chem. 2001. PMID: 12369990 Review.

10

The inhibition of protein phosphatases 1 and 2A: a new target for rational anti-cancer drug design?

McCluskey A, Ackland SP, Gardiner E, Walkom CC, Sakoff JA. McCluskey A, et al. Among authors: sakoff ja. Anticancer Drug Des. 2001 Dec;16(6):291-303. Anticancer Drug Des. 2001. PMID: 12375882

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