Hibbs MJ - Search Results

1

Development of an insect-cell-based assay for detection of kinase inhibition using NF-kappaB-inducing kinase as a paradigm.

Hassan NJ, Gul S, Flett F, Hollingsworth E, Dunne AA, Emmons AJ, Hutchinson JP, Hibbs MJ, Dyos S, Kitson JD, Hiley E, Rüdiger M, Tew DG, Powell DJ, Morse MA. Hassan NJ, et al. Among authors: hibbs mj. Biochem J. 2009 Apr 1;419(1):65-73. doi: 10.1042/BJ20081646. Biochem J. 2009. PMID: 19061480

2

High-yield production and characterization of biologically active GST-tagged human topoisomerase IIα protein in insect cells for the development of a high-throughput assay.

Singh PK, Chan PF, Hibbs MJ, Vazquez MJ, Segura DC, Thomas DA, Theobald AJ, Gallagher KT, Hassan NJ. Singh PK, et al. Among authors: hibbs mj. Protein Expr Purif. 2011 Apr;76(2):165-72. doi: 10.1016/j.pep.2010.08.001. Epub 2010 Aug 13. Protein Expr Purif. 2011. PMID: 20709174

3

Lead discovery for microsomal prostaglandin E synthase using a combination of high-throughput fluorescent-based assays and RapidFire mass spectrometry.

Leveridge MV, Bardera AI, LaMarr W, Billinton A, Bellenie B, Edge C, Francis P, Christodoulou E, Shillings A, Hibbs M, Fosberry A, Tanner R, Hardwicke P, Craggs P, Sinha Y, Elegbe O, Alvarez-Ruiz E, Martin-Plaza JJ, Barroso-Poveda V, Baddeley S, Chung CW, Hutchinson J. Leveridge MV, et al. J Biomol Screen. 2012 Jun;17(5):641-50. doi: 10.1177/1087057111435700. Epub 2012 Feb 14. J Biomol Screen. 2012. PMID: 22337655

4

Activation of complement by DMSO and ethanol and its inhibition by soluble complement receptor type 1.

Laver AJ, Hibbs M, Smith RA. Laver AJ, et al. Biochem Soc Trans. 1995 May;23(2):167S. doi: 10.1042/bst023167s. Biochem Soc Trans. 1995. PMID: 7672193 No abstract available.

5

Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase.

Jarvest RL, Erskine SG, Forrest AK, Fosberry AP, Hibbs MJ, Jones JJ, O'Hanlon PJ, Sheppard RJ, Worby A. Jarvest RL, et al. Among authors: hibbs mj. Bioorg Med Chem Lett. 2005 May 2;15(9):2305-9. doi: 10.1016/j.bmcl.2005.03.003. Bioorg Med Chem Lett. 2005. PMID: 15837314

6

Discovery and biochemical characterization of Plasmodium thioredoxin reductase inhibitors from an antimalarial set.

Theobald AJ, Caballero I, Coma I, Colmenarejo G, Cid C, Gamo FJ, Hibbs MJ, Bass AL, Thomas DA. Theobald AJ, et al. Among authors: hibbs mj. Biochemistry. 2012 Jun 12;51(23):4764-71. doi: 10.1021/bi3005076. Epub 2012 Jun 1. Biochemistry. 2012. PMID: 22612231

7

Type IIA topoisomerase inhibition by a new class of antibacterial agents.

Bax BD, Chan PF, Eggleston DS, Fosberry A, Gentry DR, Gorrec F, Giordano I, Hann MM, Hennessy A, Hibbs M, Huang J, Jones E, Jones J, Brown KK, Lewis CJ, May EW, Saunders MR, Singh O, Spitzfaden CE, Shen C, Shillings A, Theobald AJ, Wohlkonig A, Pearson ND, Gwynn MN. Bax BD, et al. Nature. 2010 Aug 19;466(7309):935-40. doi: 10.1038/nature09197. Epub 2010 Aug 4. Nature. 2010. PMID: 20686482

8

Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin.

Chan PF, Srikannathasan V, Huang J, Cui H, Fosberry AP, Gu M, Hann MM, Hibbs M, Homes P, Ingraham K, Pizzollo J, Shen C, Shillings AJ, Spitzfaden CE, Tanner R, Theobald AJ, Stavenger RA, Bax BD, Gwynn MN. Chan PF, et al. Nat Commun. 2015 Dec 7;6:10048. doi: 10.1038/ncomms10048. Nat Commun. 2015. PMID: 26640131 Free PMC article.

9

Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide.

Srikannathasan V, Wohlkonig A, Shillings A, Singh O, Chan PF, Huang J, Gwynn MN, Fosberry AP, Homes P, Hibbs M, Theobald AJ, Spitzfaden C, Bax BD. Srikannathasan V, et al. Acta Crystallogr F Struct Biol Commun. 2015 Oct;71(Pt 10):1242-6. doi: 10.1107/S2053230X15015290. Epub 2015 Sep 23. Acta Crystallogr F Struct Biol Commun. 2015. PMID: 26457513 Free PMC article.

10

Identification, cloning, and expression of a functional phenylalanyl-tRNA synthetase (pheRS) from Staphylococcus aureus.

Savopoulos JW, Hibbs M, Jones EJ, Mensah L, Richardson C, Fosberry A, Downes R, Fox SG, Brown JR, Jenkins O. Savopoulos JW, et al. Protein Expr Purif. 2001 Apr;21(3):470-84. doi: 10.1006/prep.2001.1407. Protein Expr Purif. 2001. PMID: 11281723

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