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Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C theta (PKCtheta) inhibitors.
Cole DC, Asselin M, Brennan A, Czerwinski R, Ellingboe JW, Fitz L, Greco R, Huang X, Joseph-McCarthy D, Kelly MF, Kirisits M, Lee J, Li Y, Morgan P, Stock JR, Tsao DH, Wissner A, Yang X, Chaudhary D. Cole DC, et al. Among authors: lee j. J Med Chem. 2008 Oct 9;51(19):5958-63. doi: 10.1021/jm800214a. Epub 2008 Sep 11. J Med Chem. 2008. PMID: 18783200
Optimization of 5-phenyl-3-pyridinecarbonitriles as PKCtheta inhibitors.
Boschelli DH, Wang D, Prashad AS, Subrath J, Wu B, Niu C, Lee J, Yang X, Brennan A, Chaudhary D. Boschelli DH, et al. Among authors: lee j. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3623-6. doi: 10.1016/j.bmcl.2009.04.126. Epub 2009 May 3. Bioorg Med Chem Lett. 2009. PMID: 19447612
C-5 substituted heteroaryl-3-pyridinecarbonitriles as PKCtheta inhibitors: part II.
Prashad AS, Wang D, Subrath J, Wu B, Lin M, Zhang MY, Kagan N, Lee J, Yang X, Brennan A, Chaudhary D, Xu X, Leung L, Wang J, Boschelli DH. Prashad AS, et al. Among authors: lee j. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5799-802. doi: 10.1016/j.bmcl.2009.07.113. Epub 2009 Jul 28. Bioorg Med Chem Lett. 2009. PMID: 19703774
First generation 5-vinyl-3-pyridinecarbonitrile PKCtheta inhibitors.
Niu C, Boschelli DH, Tumey LN, Bhagirath N, Subrath J, Shim J, Wang Y, Wu B, Eid C, Lee J, Yang X, Brennan A, Chaudhary D. Niu C, et al. Among authors: lee j. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5829-32. doi: 10.1016/j.bmcl.2009.08.086. Epub 2009 Aug 29. Bioorg Med Chem Lett. 2009. PMID: 19762237
148,146 results
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