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Compound A, a dissociated glucocorticoid receptor modulator, inhibits T-bet (Th1) and induces GATA-3 (Th2) activity in immune cells.
Liberman AC, Antunica-Noguerol M, Ferraz-de-Paula V, Palermo-Neto J, Castro CN, Druker J, Holsboer F, Perone MJ, Gerlo S, De Bosscher K, Haegeman G, Arzt E. Liberman AC, et al. Among authors: druker j. PLoS One. 2012;7(4):e35155. doi: 10.1371/journal.pone.0035155. Epub 2012 Apr 9. PLoS One. 2012. PMID: 22496903 Free PMC article.
The activity of the glucocorticoid receptor is regulated by SUMO conjugation to FKBP51.
Antunica-Noguerol M, Budziñski ML, Druker J, Gassen NC, Sokn MC, Senin S, Aprile-Garcia F, Holsboer F, Rein T, Liberman AC, Arzt E. Antunica-Noguerol M, et al. Among authors: druker j. Cell Death Differ. 2016 Oct;23(10):1579-91. doi: 10.1038/cdd.2016.44. Epub 2016 May 13. Cell Death Differ. 2016. PMID: 27177020 Free PMC article.
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