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Page 1
Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: a novel, potent and orally active direct inhibitor of factor Xa.
Nagata T, Yoshino T, Haginoya N, Yoshikawa K, Nagamochi M, Kobayashi S, Komoriya S, Yokomizo A, Muto R, Yamaguchi M, Osanai K, Suzuki M, Kanno H. Nagata T, et al. Among authors: haginoya n. Bioorg Med Chem. 2009 Feb 1;17(3):1193-206. doi: 10.1016/j.bmc.2008.12.037. Epub 2008 Dec 24. Bioorg Med Chem. 2009. PMID: 19128974
Design, synthesis, and biological activity of novel factor Xa inhibitors: improving metabolic stability by S1 and S4 ligand modification.
Komoriya S, Kobayashi S, Osanai K, Yoshino T, Nagata T, Haginoya N, Nakamoto Y, Mochizuki A, Nagahara T, Suzuki M, Shimada T, Watanabe K, Isobe Y, Furugoori T. Komoriya S, et al. Among authors: haginoya n. Bioorg Med Chem. 2006 Mar 1;14(5):1309-30. doi: 10.1016/j.bmc.2005.09.056. Epub 2005 Nov 2. Bioorg Med Chem. 2006. PMID: 16263291
Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: exploration of 5-6 fused rings as alternative S1 moieties.
Yoshikawa K, Yokomizo A, Naito H, Haginoya N, Kobayashi S, Yoshino T, Nagata T, Mochizuki A, Osanai K, Watanabe K, Kanno H, Ohta T. Yoshikawa K, et al. Among authors: haginoya n. Bioorg Med Chem. 2009 Dec 15;17(24):8206-20. doi: 10.1016/j.bmc.2009.10.023. Epub 2009 Oct 31. Bioorg Med Chem. 2009. PMID: 19884015
Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: exploration of 6-6 fused rings as alternative S1 moieties.
Yoshikawa K, Kobayashi S, Nakamoto Y, Haginoya N, Komoriya S, Yoshino T, Nagata T, Mochizuki A, Watanabe K, Suzuki M, Kanno H, Ohta T. Yoshikawa K, et al. Among authors: haginoya n. Bioorg Med Chem. 2009 Dec 15;17(24):8221-33. doi: 10.1016/j.bmc.2009.10.024. Epub 2009 Oct 17. Bioorg Med Chem. 2009. PMID: 19900814
18 results