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Targeting receptor kinases by a novel indolinone derivative in multiple myeloma: abrogation of stroma-derived interleukin-6 secretion and induction of apoptosis in cytogenetically defined subgroups.
Bisping G, Kropff M, Wenning D, Dreyer B, Bessonov S, Hilberg F, Roth GJ, Munzert G, Stefanic M, Stelljes M, Scheffold C, Müller-Tidow C, Liebisch P, Lang N, Tchinda J, Serve HL, Mesters RM, Berdel WE, Kienast J. Bisping G, et al. Among authors: roth gj. Blood. 2006 Mar 1;107(5):2079-89. doi: 10.1182/blood-2004-11-4250. Epub 2005 Nov 8. Blood. 2006. PMID: 16278310 Free article.
Growth inhibition and induction of apoptosis in acute myeloid leukemia cells by new indolinone derivatives targeting fibroblast growth factor, platelet-derived growth factor, and vascular endothelial growth factor receptors.
Kulimova E, Oelmann E, Bisping G, Kienast J, Mesters RM, Schwäble J, Hilberg F, Roth GJ, Munzert G, Stefanic M, Steffen B, Brandts C, Müller-Tidow C, Kolkmeyer A, Büchner T, Serve H, Berdel WE. Kulimova E, et al. Among authors: roth gj. Mol Cancer Ther. 2006 Dec;5(12):3105-12. doi: 10.1158/1535-7163.MCT-06-0323. Mol Cancer Ther. 2006. PMID: 17172413
Inhibition of PDGF, VEGF and FGF signalling attenuates fibrosis.
Chaudhary NI, Roth GJ, Hilberg F, Müller-Quernheim J, Prasse A, Zissel G, Schnapp A, Park JE. Chaudhary NI, et al. Among authors: roth gj. Eur Respir J. 2007 May;29(5):976-85. doi: 10.1183/09031936.00152106. Epub 2007 Feb 14. Eur Respir J. 2007. PMID: 17301095 Free article.
Nintedanib: from discovery to the clinic.
Roth GJ, Binder R, Colbatzky F, Dallinger C, Schlenker-Herceg R, Hilberg F, Wollin SL, Kaiser R. Roth GJ, et al. J Med Chem. 2015 Feb 12;58(3):1053-63. doi: 10.1021/jm501562a. Epub 2015 Jan 14. J Med Chem. 2015. PMID: 25474320 Review.
Phenocopy--a strategy to qualify chemical compounds during hit-to-lead and/or lead optimization.
Baum P, Schmid R, Ittrich C, Rust W, Fundel-Clemens K, Siewert S, Baur M, Mara L, Gruenbaum L, Heckel A, Eils R, Kontermann RE, Roth GJ, Gantner F, Schnapp A, Park JE, Weith A, Quast K, Mennerich D. Baum P, et al. Among authors: roth gj. PLoS One. 2010 Dec 10;5(12):e14272. doi: 10.1371/journal.pone.0014272. PLoS One. 2010. PMID: 21170314 Free PMC article.
86 results