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Proteolytic activation of the 1918 influenza virus hemagglutinin.
Chaipan C, Kobasa D, Bertram S, Glowacka I, Steffen I, Tsegaye TS, Takeda M, Bugge TH, Kim S, Park Y, Marzi A, Pöhlmann S. Chaipan C, et al. Among authors: takeda m. J Virol. 2009 Apr;83(7):3200-11. doi: 10.1128/JVI.02205-08. Epub 2009 Jan 21. J Virol. 2009. PMID: 19158246 Free PMC article.
The host protease TMPRSS2 plays a major role in in vivo replication of emerging H7N9 and seasonal influenza viruses.
Sakai K, Ami Y, Tahara M, Kubota T, Anraku M, Abe M, Nakajima N, Sekizuka T, Shirato K, Suzaki Y, Ainai A, Nakatsu Y, Kanou K, Nakamura K, Suzuki T, Komase K, Nobusawa E, Maenaka K, Kuroda M, Hasegawa H, Kawaoka Y, Tashiro M, Takeda M. Sakai K, et al. Among authors: takeda m. J Virol. 2014 May;88(10):5608-16. doi: 10.1128/JVI.03677-13. Epub 2014 Mar 5. J Virol. 2014. PMID: 24600012 Free PMC article.
A mutant H3N2 influenza virus uses an alternative activation mechanism in TMPRSS2 knockout mice by loss of an oligosaccharide in the hemagglutinin stalk region.
Sakai K, Sekizuka T, Ami Y, Nakajima N, Kitazawa M, Sato Y, Nakajima K, Anraku M, Kubota T, Komase K, Takehara K, Hasegawa H, Odagiri T, Tashiro M, Kuroda M, Takeda M. Sakai K, et al. Among authors: takeda m. J Virol. 2015 May;89(9):5154-8. doi: 10.1128/JVI.00124-15. Epub 2015 Feb 11. J Virol. 2015. PMID: 25673722 Free PMC article.
4,091 results