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Page 1
RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes.
Coughlan MT, Thorburn DR, Penfold SA, Laskowski A, Harcourt BE, Sourris KC, Tan AL, Fukami K, Thallas-Bonke V, Nawroth PP, Brownlee M, Bierhaus A, Cooper ME, Forbes JM. Coughlan MT, et al. Among authors: bierhaus a. J Am Soc Nephrol. 2009 Apr;20(4):742-52. doi: 10.1681/ASN.2008050514. Epub 2009 Jan 21. J Am Soc Nephrol. 2009. PMID: 19158353 Free PMC article.
Receptor for advanced glycation end products (RAGE) deficiency attenuates the development of atherosclerosis in diabetes.
Soro-Paavonen A, Watson AM, Li J, Paavonen K, Koitka A, Calkin AC, Barit D, Coughlan MT, Drew BG, Lancaster GI, Thomas M, Forbes JM, Nawroth PP, Bierhaus A, Cooper ME, Jandeleit-Dahm KA. Soro-Paavonen A, et al. Among authors: bierhaus a. Diabetes. 2008 Sep;57(9):2461-9. doi: 10.2337/db07-1808. Epub 2008 May 28. Diabetes. 2008. PMID: 18511846 Free PMC article.
Disparate effects on renal and oxidative parameters following RAGE deletion, AGE accumulation inhibition, or dietary AGE control in experimental diabetic nephropathy.
Tan AL, Sourris KC, Harcourt BE, Thallas-Bonke V, Penfold S, Andrikopoulos S, Thomas MC, O'Brien RC, Bierhaus A, Cooper ME, Forbes JM, Coughlan MT. Tan AL, et al. Among authors: bierhaus a. Am J Physiol Renal Physiol. 2010 Mar;298(3):F763-70. doi: 10.1152/ajprenal.00591.2009. Epub 2009 Dec 16. Am J Physiol Renal Physiol. 2010. PMID: 20015941 Free article.
Targeted reduction of advanced glycation improves renal function in obesity.
Harcourt BE, Sourris KC, Coughlan MT, Walker KZ, Dougherty SL, Andrikopoulos S, Morley AL, Thallas-Bonke V, Chand V, Penfold SA, de Courten MP, Thomas MC, Kingwell BA, Bierhaus A, Cooper ME, de Courten B, Forbes JM. Harcourt BE, et al. Among authors: bierhaus a. Kidney Int. 2011 Jul;80(2):190-8. doi: 10.1038/ki.2011.57. Epub 2011 Mar 16. Kidney Int. 2011. PMID: 21412218 Free article. Clinical Trial.
Receptor for AGEs (RAGE) blockade may exert its renoprotective effects in patients with diabetic nephropathy via induction of the angiotensin II type 2 (AT2) receptor.
Sourris KC, Morley AL, Koitka A, Samuel P, Coughlan MT, Penfold SA, Thomas MC, Bierhaus A, Nawroth PP, Yamamoto H, Allen TJ, Walther T, Hussain T, Cooper ME, Forbes JM. Sourris KC, et al. Among authors: bierhaus a. Diabetologia. 2010 Nov;53(11):2442-51. doi: 10.1007/s00125-010-1837-2. Epub 2010 Jul 15. Diabetologia. 2010. PMID: 20631980 Free PMC article.
Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes.
Forbes JM, Söderlund J, Yap FY, Knip M, Andrikopoulos S, Ilonen J, Simell O, Veijola R, Sourris KC, Coughlan MT, Forsblom C, Slattery R, Grey ST, Wessman M, Yamamoto H, Bierhaus A, Cooper ME, Groop PH. Forbes JM, et al. Among authors: bierhaus a. Diabetologia. 2011 May;54(5):1032-42. doi: 10.1007/s00125-011-2058-z. Epub 2011 Feb 6. Diabetologia. 2011. PMID: 21298413
249 results