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Page 1
Discovery of small molecule human C5a receptor antagonists.
Sanganee HJ, Baxter A, Barber S, Brown AJ, Grice D, Hunt F, King S, Laughton D, Pairaudeau G, Thong B, Weaver R, Unitt J. Sanganee HJ, et al. Among authors: weaver r. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1143-7. doi: 10.1016/j.bmcl.2008.12.104. Epub 2008 Dec 31. Bioorg Med Chem Lett. 2009. PMID: 19171482
Discovery of pyrazoles as novel FPR1 antagonists.
Morley AD, Cook A, King S, Roberts B, Lever S, Weaver R, Macdonald C, Unitt J, Fagura M, Phillips T, Lewis R, Wenlock M. Morley AD, et al. Among authors: weaver r. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6456-60. doi: 10.1016/j.bmcl.2011.08.085. Epub 2011 Sep 6. Bioorg Med Chem Lett. 2011. PMID: 21955939
Discovery of potent CRTh2 (DP2) receptor antagonists.
Birkinshaw TN, Teague SJ, Beech C, Bonnert RV, Hill S, Patel A, Reakes S, Sanganee H, Dougall IG, Phillips TT, Salter S, Schmidt J, Arrowsmith EC, Carrillo JJ, Bell FM, Paine SW, Weaver R. Birkinshaw TN, et al. Among authors: weaver r. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4287-90. doi: 10.1016/j.bmcl.2006.05.062. Epub 2006 Jun 5. Bioorg Med Chem Lett. 2006. PMID: 16753296
Discovery of small molecule human FPR1 receptor antagonists.
Unitt J, Fagura M, Phillips T, King S, Perry M, Morley A, MacDonald C, Weaver R, Christie J, Barber S, Mohammed R, Paul M, Cook A, Baxter A. Unitt J, et al. Among authors: weaver r. Bioorg Med Chem Lett. 2011 May 15;21(10):2991-7. doi: 10.1016/j.bmcl.2011.03.049. Epub 2011 Mar 21. Bioorg Med Chem Lett. 2011. PMID: 21486695
Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors.
Furber M, Alcaraz L, Bent JE, Beyerbach A, Bowers K, Braddock M, Caffrey MV, Cladingboel D, Collington J, Donald DK, Fagura M, Ince F, Kinchin EC, Laurent C, Lawson M, Luker TJ, Mortimore MM, Pimm AD, Riley RJ, Roberts N, Robertson M, Theaker J, Thorne PV, Weaver R, Webborn P, Willis P. Furber M, et al. Among authors: weaver r. J Med Chem. 2007 Nov 29;50(24):5882-5. doi: 10.1021/jm700949w. Epub 2007 Oct 27. J Med Chem. 2007. PMID: 17963373
Time-dependent CYP inhibition.
Riley RJ, Grime K, Weaver R. Riley RJ, et al. Among authors: weaver r. Expert Opin Drug Metab Toxicol. 2007 Feb;3(1):51-66. doi: 10.1517/17425255.3.1.51. Expert Opin Drug Metab Toxicol. 2007. PMID: 17269894 Review.
Identification and quantification of glutathione adducts of clozapine using ultra-high-performance liquid chromatography with orthogonal acceleration time-of-flight mass spectrometry and inductively coupled plasma mass spectrometry.
MacDonald C, Smith C, Michopoulos F, Weaver R, Wilson ID. MacDonald C, et al. Among authors: weaver r. Rapid Commun Mass Spectrom. 2011 Jul 15;25(13):1787-93. doi: 10.1002/rcm.5043. Rapid Commun Mass Spectrom. 2011. PMID: 21638353
1,132 results