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BI-69A11-mediated inhibition of AKT leads to effective regression of xenograft melanoma.
Gaitonde S, De SK, Tcherpakov M, Dewing A, Yuan H, Riel-Mehan M, Krajewski S, Robertson G, Pellecchia M, Ronai Z. Gaitonde S, et al. Among authors: pellecchia m. Pigment Cell Melanoma Res. 2009 Apr;22(2):187-95. doi: 10.1111/j.1755-148X.2009.00544.x. Epub 2009 Jan 17. Pigment Cell Melanoma Res. 2009. PMID: 19175524 Free PMC article.
Identification of a new JNK inhibitor targeting the JNK-JIP interaction site.
Stebbins JL, De SK, Machleidt T, Becattini B, Vazquez J, Kuntzen C, Chen LH, Cellitti JF, Riel-Mehan M, Emdadi A, Solinas G, Karin M, Pellecchia M. Stebbins JL, et al. Among authors: pellecchia m. Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16809-13. doi: 10.1073/pnas.0805677105. Epub 2008 Oct 15. Proc Natl Acad Sci U S A. 2008. PMID: 18922779 Free PMC article.
Design, synthesis, and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-Jun N-terminal kinase.
De SK, Stebbins JL, Chen LH, Riel-Mehan M, Machleidt T, Dahl R, Yuan H, Emdadi A, Barile E, Chen V, Murphy R, Pellecchia M. De SK, et al. Among authors: pellecchia m. J Med Chem. 2009 Apr 9;52(7):1943-52. doi: 10.1021/jm801503n. J Med Chem. 2009. PMID: 19271755 Free PMC article.
Discovery and binding studies on a series of novel Pin1 ligands.
Wu B, Rega MF, Wei J, Yuan H, Dahl R, Zhang Z, Pellecchia M. Wu B, et al. Among authors: pellecchia m. Chem Biol Drug Des. 2009 Apr;73(4):369-79. doi: 10.1111/j.1747-0285.2009.00795.x. Chem Biol Drug Des. 2009. PMID: 19291099 Free PMC article.
472 results