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The N-terminal tripeptide of insulin-like growth factor-I protects against beta-amyloid-induced somatostatin depletion by calcium and glycogen synthase kinase 3 beta modulation.
Burgos-Ramos E, Martos-Moreno GA, López MG, Herranz R, Aguado-Llera D, Egea J, Frechilla D, Cenarruzabeitia E, León R, Arilla-Ferreiro E, Argente J, Barrios V. Burgos-Ramos E, et al. J Neurochem. 2009 Apr;109(2):360-70. doi: 10.1111/j.1471-4159.2009.05980.x. Epub 2009 Feb 11. J Neurochem. 2009. PMID: 19220704 Free article.
Chronic but not acute intracerebroventricular administration of amyloid beta-peptide(25-35) decreases somatostatin content, adenylate cyclase activity, somatostatin-induced inhibition of adenylate cyclase activity, and adenylate cyclase I levels in the rat hippocampus.
Burgos-Ramos E, Hervás-Aguilar A, Puebla-Jiménez L, Boyano-Adánez MC, Arilla-Ferreiro E. Burgos-Ramos E, et al. J Neurosci Res. 2007 Feb 1;85(2):433-42. doi: 10.1002/jnr.21115. J Neurosci Res. 2007. PMID: 17086550
Somatostatin and Alzheimer's disease.
Burgos-Ramos E, Hervás-Aguilar A, Aguado-Llera D, Puebla-Jiménez L, Hernández-Pinto AM, Barrios V, Arilla-Ferreiro E. Burgos-Ramos E, et al. Mol Cell Endocrinol. 2008 May 14;286(1-2):104-11. doi: 10.1016/j.mce.2008.01.014. Epub 2008 Feb 3. Mol Cell Endocrinol. 2008. PMID: 18359553 Review.
43 results