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The Lewis-Y carbohydrate antigen is expressed by many human tumors and can serve as a target for genetically redirected T cells despite the presence of soluble antigen in serum.
Westwood JA, Murray WK, Trivett M, Haynes NM, Solomon B, Mileshkin L, Ball D, Michael M, Burman A, Mayura-Guru P, Trapani JA, Peinert S, Hönemann D, Miles Prince H, Scott AM, Smyth MJ, Darcy PK, Kershaw MH. Westwood JA, et al. J Immunother. 2009 Apr;32(3):292-301. doi: 10.1097/CJI.0b013e31819b7c8e. J Immunother. 2009. PMID: 19242371
Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice.
Westwood JA, Smyth MJ, Teng MW, Moeller M, Trapani JA, Scott AM, Smyth FE, Cartwright GA, Power BE, Hönemann D, Prince HM, Darcy PK, Kershaw MH. Westwood JA, et al. Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19051-6. doi: 10.1073/pnas.0504312102. Epub 2005 Dec 19. Proc Natl Acad Sci U S A. 2005. PMID: 16365285 Free PMC article.
Genetic redirection of T cells for cancer therapy.
Westwood JA, Kershaw MH. Westwood JA, et al. J Leukoc Biol. 2010 May;87(5):791-803. doi: 10.1189/jlb.1209824. Epub 2010 Feb 23. J Leukoc Biol. 2010. PMID: 20179152 Review.
Tumor ablation by gene-modified T cells in the absence of autoimmunity.
Wang LX, Westwood JA, Moeller M, Duong CP, Wei WZ, Malaterre J, Trapani JA, Neeson P, Smyth MJ, Kershaw MH, Darcy PK. Wang LX, et al. Among authors: westwood ja. Cancer Res. 2010 Dec 1;70(23):9591-8. doi: 10.1158/0008-5472.CAN-10-2884. Epub 2010 Nov 23. Cancer Res. 2010. PMID: 21098715
Gene-engineered T cells for cancer therapy.
Kershaw MH, Westwood JA, Darcy PK. Kershaw MH, et al. Among authors: westwood ja. Nat Rev Cancer. 2013 Aug;13(8):525-41. doi: 10.1038/nrc3565. Nat Rev Cancer. 2013. PMID: 23880905 Review.
54 results