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A high number of losses in 13q14 chromosome band is associated with a worse outcome and biological differences in patients with B-cell chronic lymphoid leukemia.
Hernández JA, Rodríguez AE, González M, Benito R, Fontanillo C, Sandoval V, Romero M, Martín-Núñez G, de Coca AG, Fisac R, Galende J, Recio I, Ortuño F, García JL, de las Rivas J, Gutiérrez NC, San Miguel JF, Hernández JM. Hernández JA, et al. Among authors: ortuno f. Haematologica. 2009 Mar;94(3):364-71. doi: 10.3324/haematol.13862. Haematologica. 2009. PMID: 19252174 Free PMC article.
Immunophenotypic analysis of myelodysplastic syndromes.
Del Cañizo MC, Fernández ME, López A, Vidriales B, Villarón E, Arroyo JL, Ortuño F, Orfao A, San Miguel JF. Del Cañizo MC, et al. Among authors: ortuno f. Haematologica. 2003 Apr;88(4):402-7. Haematologica. 2003. PMID: 12681967
Immunophenotyping of acute leukemias and myelodysplastic syndromes.
Orfao A, Ortuño F, de Santiago M, Lopez A, San Miguel J. Orfao A, et al. Among authors: ortuno f. Cytometry A. 2004 Mar;58(1):62-71. doi: 10.1002/cyto.a.10104. Cytometry A. 2004. PMID: 14994223 Free article. Review. No abstract available.
Interstitial 13q14 deletions detected in the karyotype and translocations with concomitant deletion at 13q14 in chronic lymphocytic leukemia: different genetic mechanisms but equivalent poorer clinical outcome.
Puiggros A, Venturas M, Salido M, Blanco G, Fernandez-Rodriguez C, Collado R, Valiente A, Ruiz-Xivillé N, Carrió A, Ortuño FJ, Luño E, Calasanz MJ, Ardanaz MT, Piñán MÁ, Talavera E, González MT, Ortega M, Marugán I, Ferrer A, Gimeno E, Bellosillo B, Delgado J, Hernández JÁ, Hernández-Rivas JM, Espinet B; Grupo Cooperativo Español de Citogenética Hematológica (GCECGH); Grupo Español de Leucemia Linfática Crónica (GELLC). Puiggros A, et al. Genes Chromosomes Cancer. 2014 Sep;53(9):788-97. doi: 10.1002/gcc.22188. Epub 2014 Jun 10. Genes Chromosomes Cancer. 2014. PMID: 24915757
Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations.
Blanco G, Puiggros A, Baliakas P, Athanasiadou A, García-Malo M, Collado R, Xochelli A, Rodríguez-Rivera M, Ortega M, Calasanz MJ, Luño E, Vargas M, Grau J, Martínez-Laperche C, Valiente A, Cervera J, Anagnostopoulos A, Gimeno E, Abella E, Stalika E, Hernández-Rivas JM, Ortuño FJ, Robles D, Ferrer A, Ivars D, González M, Bosch F, Abrisqueta P, Stamatopoulos K, Espinet B. Blanco G, et al. Among authors: ortuno fj. Oncotarget. 2016 Dec 6;7(49):80916-80924. doi: 10.18632/oncotarget.13106. Oncotarget. 2016. PMID: 27821812 Free PMC article.
Patients with chronic lymphocytic leukemia and complex karyotype show an adverse outcome even in absence of TP53/ATM FISH deletions.
Puiggros A, Collado R, Calasanz MJ, Ortega M, Ruiz-Xivillé N, Rivas-Delgado A, Luño E, González T, Navarro B, García-Malo M, Valiente A, Hernández JÁ, Ardanaz MT, Piñan MÁ, Blanco ML, Hernández-Sánchez M, Batlle-López A, Salgado R, Salido M, Ferrer A, Abrisqueta P, Gimeno E, Abella E, Ferrá C, Terol MJ, Ortuño F, Costa D, Moreno C, Carbonell F, Bosch F, Delgado J, Espinet B. Puiggros A, et al. Among authors: ortuno f. Oncotarget. 2017 Apr 21;8(33):54297-54303. doi: 10.18632/oncotarget.17350. eCollection 2017 Aug 15. Oncotarget. 2017. PMID: 28903342 Free PMC article.
Genetic abnormalities and clinical outcome in chronic lymphocytic leukemia.
Ripollés L, Ortega M, Ortuño F, González A, Losada J, Ojanguren J, Soler JA, Bergua J, Coll MD, Caballín MR. Ripollés L, et al. Among authors: ortuno f. Cancer Genet Cytogenet. 2006 Nov;171(1):57-64. doi: 10.1016/j.cancergencyto.2006.07.006. Cancer Genet Cytogenet. 2006. PMID: 17074592
182 results